Detailed information of TA system TA211890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2538205..2539927
• Replicon: chromosome
• Accession: NZ_CP080462
• Organism: Vibrio cholerae strain ICDC-VC702

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: K1T74_RS11625
• Protein ID: WP_220105804.1
• Coordinates: 2538205..2539143 (-)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: K1T74_RS11630
• Protein ID: WP_220106262.1
• Coordinates: 2539136..2539927 (-)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T74_RS11605	2534146..2534658	-	513	WP_193021830.1	S26 family signal peptidase	-
K1T74_RS11610	2534642..2534989	-	348	WP_011788500.1	hypothetical protein	-
K1T74_RS11615	2534982..2537381	-	2400	WP_220105803.1	type IV secretion system protein TraC	-
K1T74_RS11620	2537381..2538073	-	693	WP_001228924.1	DsbC family protein	-
K1T74_RS11625	2538205..2539143	-	939	WP_220105804.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
K1T74_RS11630	2539136..2539927	-	792	WP_220106262.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
K1T74_RS11635	2540148..2540534	-	387	WP_004249359.1	TraA family conjugative transfer protein	-
K1T74_RS11640	2540531..2541103	-	573	WP_220105805.1	TraV family lipoprotein	-
K1T74_RS11645	2541178..2542467	-	1290	WP_014703136.1	TraB/VirB10 family protein	-
K1T74_RS11650	2542470..2543366	-	897	WP_220106263.1	type-F conjugative transfer system secretin TraK	-
K1T74_RS11655	2543350..2543976	-	627	WP_023584040.1	TraE/TraK family type IV conjugative transfer system protein	-
K1T74_RS11660	2543973..2544254	-	282	WP_206624354.1	type IV conjugative transfer system protein TraL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2442417..2577043	134626

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-279)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-97)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35578.85 Da
• Isoelectric Point: 4.9081

>T211890 WP_220105804.1 NZ_CP080462:c2539143-2538205 [Vibrio cholerae]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWTLFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

>T211890 NZ_CP106825:3393-3671 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30153.50 Da
• Isoelectric Point: 9.3513

>AT211890 WP_220106262.1 NZ_CP080462:c2539927-2539136 [Vibrio cholerae]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLDVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDGIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT211890 NZ_CP106825:3208-3393 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA