Detailed information of TA system TA211889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2325072..2326897
• Replicon: chromosome
• Accession: NZ_CP080462
• Organism: Vibrio cholerae strain ICDC-VC702

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K1T74_RS10695
• Protein ID: WP_171356568.1
• Coordinates: 2325072..2326433 (+)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K1T74_RS10700
• Protein ID: WP_071180723.1
• Coordinates: 2326430..2326897 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K1T74_RS10665	2320530..2320976	+	447	WP_032468964.1	DUF2787 domain-containing protein	-
K1T74_RS10670	2321083..2322069	+	987	WP_220105754.1	GTPase family protein	-
K1T74_RS10675	2322104..2322745	-	642	WP_220105755.1	inovirus Gp2 family protein	-
K1T74_RS10680	2323126..2323464	+	339	WP_220105756.1	hypothetical protein	-
K1T74_RS10685	2323752..2324144	+	393	WP_238844543.1	hypothetical protein	-
K1T74_RS10690	2324237..2324437	-	201	WP_019830047.1	AlpA family transcriptional regulator	-
K1T74_RS10695	2325072..2326433	+	1362	WP_171356568.1	type II toxin-antitoxin system HipA family toxin	Toxin
K1T74_RS10700	2326430..2326897	+	468	WP_071180723.1	helix-turn-helix transcriptional regulator	Antitoxin
K1T74_RS10705	2327325..2327903	+	579	WP_000109982.1	class I SAM-dependent methyltransferase	-
K1T74_RS10710	2327907..2330843	+	2937	WP_171356567.1	DEAD/DEAH box helicase family protein	-
K1T74_RS10715	2330913..2331614	+	702	Protein_2088	NERD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2314891..2332461	17570

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-367)

Antitoxin

• Cro/C1-type helix-turn-helix domain (80-138)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51323.19 Da
• Isoelectric Point: 4.9109

>T211889 WP_171356568.1 NZ_CP080462:2325072-2326433 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPGGIPRTTKWKAPLEFGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEIPAVGLNYLSEKLTKWGLL

Nucleotide

• Length: 1362 bp

>T211889 NZ_CP106824:c1661914-1661732 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17020.49 Da
• Isoelectric Point: 10.7084

>AT211889 WP_071180723.1 NZ_CP080462:2326430-2326897 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKSATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Nucleotide

• Length: 468 bp

>AT211889 NZ_CP106824:c1661630-1661229 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG