Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 158358..160033 Replicon chromosome
Accession NZ_CP080462
Organism Vibrio cholerae strain ICDC-VC702

Toxin (Protein)


Gene name panT Uniprot ID A0A0X8LPQ1
Locus tag K1T74_RS00785 Protein ID WP_001280596.1
Coordinates 158822..160033 (+) Length 404 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0X8LPP8
Locus tag K1T74_RS00780 Protein ID WP_000649312.1
Coordinates 158358..158825 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T74_RS19680 155555..156040 + 486 WP_202899963.1 hypothetical protein -
K1T74_RS00770 156037..157401 + 1365 WP_039541773.1 hypothetical protein -
K1T74_RS00775 157401..158168 + 768 WP_000230362.1 TatD family hydrolase -
K1T74_RS00780 158358..158825 + 468 WP_000649312.1 DUF4065 domain-containing protein Antitoxin
K1T74_RS00785 158822..160033 + 1212 WP_001280596.1 RelA/SpoT domain-containing protein Toxin
K1T74_RS00790 160277..161386 - 1110 WP_148521693.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
K1T74_RS00795 161784..163616 + 1833 WP_001898833.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(86-226)

Antitoxin

Antitoxin SocA-like, Panacea domain

(32-123)


Sequences

Toxin        


Download         Length: 404 a.a.        Molecular weight: 45837.66 Da        Isoelectric Point: 5.2762

>T211888 WP_001280596.1 NZ_CP080462:158822-160033 [Vibrio cholerae]
VSDKEKRVVSFQIDDTPTAEQASKNFQDDYELCFQDFLERTVDESAAEDFSYSNNGVKKAGRRLRKKEGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIVDKLQRKSLDGETTNATCVTNMNDIGGCRAIFPDLESLEKA
KERLQVTVEKVGRIKIKDIDDYITNPKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIK
THSHSPDEDKEKLQVQWEELLSIMSQYIADAEGAIELSNDNRTQFSNRLIELNREINALSRLRSFKILSEKVEGCRDGSI
EHVLLVIDETSLEMIFSEEFENYTQAISVYNAAEKMTRSHARLNTLLISTKNMGQLSEAYPNYLGDCASFITLLEDAMQS
GQN

Download         Length: 1212 bp

>T211888 NZ_CP106824:656899-657318 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17581.02 Da        Isoelectric Point: 7.5659

>AT211888 WP_000649312.1 NZ_CP080462:158358-158825 [Vibrio cholerae]
MKAYHTYSAVDVAWSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGSNVI
TEQCDVVLDHESESIVKDVVSQLGHLTGPQLVDLTHREGSPWHQVWDGTHQKVIPDHLIQAHYTQIKQSGRTASL

Download         Length: 468 bp

>AT211888 NZ_CP106824:656663-656899 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8LPQ1

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8LPP8

References