Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2564943..2565454 Replicon chromosome
Accession NZ_CP080458
Organism Staphylococcus carnosus strain KCTC 3580

Toxin (Protein)


Gene name TsdT Uniprot ID B9DMH5
Locus tag Sta3580_RS12625 Protein ID WP_015900832.1
Coordinates 2564943..2565149 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag Sta3580_RS12630 Protein ID WP_015900833.1
Coordinates 2565161..2565454 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Sta3580_RS12605 (Sta3580_12570) 2560916..2562133 + 1218 WP_015900829.1 FtsW/RodA/SpoVE family cell cycle protein -
Sta3580_RS12610 (Sta3580_12575) 2562205..2562345 - 141 WP_167313208.1 Lmo0850 family protein -
Sta3580_RS12615 (Sta3580_12580) 2562421..2564622 - 2202 WP_015900830.1 heavy metal translocating P-type ATPase -
Sta3580_RS12620 (Sta3580_12585) 2564719..2564928 - 210 WP_015900831.1 copper ion binding protein -
Sta3580_RS12625 (Sta3580_12590) 2564943..2565149 - 207 WP_015900832.1 heavy metal-associated domain-containing protein Toxin
Sta3580_RS12630 (Sta3580_12595) 2565161..2565454 - 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
Sta3580_RS12635 (Sta3580_12600) 2565619..2567100 + 1482 WP_015900834.1 cardiolipin synthase -
Sta3580_RS12640 (Sta3580_12605) 2567125..2567772 + 648 WP_015900835.1 HD domain-containing protein -
Sta3580_RS12645 (Sta3580_12610) 2567863..2568375 - 513 WP_015900836.1 GNAT family N-acetyltransferase -
Sta3580_RS12650 (Sta3580_12615) 2568486..2569355 - 870 WP_015900837.1 membrane protein insertase YidC -
Sta3580_RS12655 (Sta3580_12620) 2569444..2570082 - 639 WP_015900838.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7833.72 Da        Isoelectric Point: 4.1353

>T211887 WP_015900832.1 NZ_CP080458:c2565149-2564943 [Staphylococcus carnosus]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVSAVQVDMDSNEVRISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

>T211887 NZ_CP106823:1973-2251 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT211887 WP_015900833.1 NZ_CP080458:c2565454-2565161 [Staphylococcus carnosus]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT211887 NZ_CP106823:1788-1973 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380F432

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References