Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2551580..2552094 Replicon chromosome
Accession NZ_CP080458
Organism Staphylococcus carnosus strain KCTC 3580

Toxin (Protein)


Gene name mazF Uniprot ID A0A3G4R0E2
Locus tag Sta3580_RS12555 Protein ID WP_075140914.1
Coordinates 2551580..2551930 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B9DMI8
Locus tag Sta3580_RS12560 Protein ID WP_015900820.1
Coordinates 2551927..2552094 (-) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Sta3580_RS12535 (Sta3580_12500) 2548607..2549377 - 771 WP_015900815.1 RNA polymerase sigma factor SigB -
Sta3580_RS12540 (Sta3580_12505) 2549352..2549831 - 480 WP_015900816.1 anti-sigma B factor RsbW -
Sta3580_RS12545 (Sta3580_12510) 2549833..2550159 - 327 WP_015900817.1 anti-sigma factor antagonist -
Sta3580_RS12550 (Sta3580_12515) 2550235..2551236 - 1002 WP_015900818.1 PP2C family protein-serine/threonine phosphatase -
Sta3580_RS12555 (Sta3580_12520) 2551580..2551930 - 351 WP_075140914.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
Sta3580_RS12560 (Sta3580_12525) 2551927..2552094 - 168 WP_015900820.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
Sta3580_RS12565 (Sta3580_12530) 2552175..2553329 - 1155 WP_015900821.1 alanine racemase -
Sta3580_RS12570 (Sta3580_12535) 2553393..2553746 - 354 WP_015900822.1 holo-ACP synthase -
Sta3580_RS12575 (Sta3580_12540) 2553748..2554248 - 501 WP_115314364.1 PH domain-containing protein -
Sta3580_RS12580 (Sta3580_12545) 2554238..2555725 - 1488 WP_015900824.1 PH domain-containing protein -
Sta3580_RS12585 (Sta3580_12550) 2555718..2556188 - 471 WP_015900825.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13075.18 Da        Isoelectric Point: 10.0708

>T211886 WP_075140914.1 NZ_CP080458:c2551930-2551580 [Staphylococcus carnosus]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIQISLGLTHRN

Download         Length: 351 bp

>T211886 NZ_CP106822:16039-17244 [Neisseria gonorrhoeae]
ATGGTAAAACTGTCTAGCGATATTAATCTGAGAGATTTTGGCAATAACGAATATTTGTCTTCCGTTCAGGATGAGGCCAT
CCGTTTTGCGACCGAACAAACAGACGAGATATTGTCTTTATATAGCCAACATGCAGATACAGAAGGCGGTAGATATGTTT
GTGCTGATACGTTTAAAGAGTTGTTTCCAGCTTTTGAGAACAAAGAAGACAGGGCAACGGTTAATAATGCCATCCACAAT
TCAGCAGCAGTTTTATCTTCTACCCAGTTTGACGAGGTACTGAAACGCGACGAGCCACAGAAGAAAGAAGTTATTTTCGT
TACGGGAATTCCGGGTTCGGGAAAAACTTCGACAGTAAAAAACATGATGATGCAGGATACCACCAAGCTGCTTTTTGAAG
GACAGCTTGCACGGCCGCAGTCTGCTTTTCGCAAGATTGAGCAGTGTCTGGAGCGTAATCTTGAAGTTACTATCGTAGCC
GTCAGCATGAGGGCTGAAAGGGCTTCCGACAATACTTACAAACGGTTTAACGAATACGGCAGGGAAGCCAGTATAGGTAT
TATGGCTGATATTCAGGCCAATCTTCCTGACGGACTCAAGCAAATCAGGGATAAGTTTGGTGATGCGGTAAAAATTGTCG
GTATCAACCAAGACAGGAACAGTGAATTTATCGACAAGTTCGATGATGTCATCAAAATGCTTTCCTTGGGGTCGCAAGAG
CAAATATTGGGCAGGTTGGCCGAGAAAATCCAGAGCGACTTCGACTCAGGAAAAATCAGCCGGGAATGCTTCAATCAGGC
CAAGGGCAGTATGGATCTTGAAAGTGTTTTCGCCAAAAAAGAGTATTCCCAGCAAAGGGTAGTTACTAACTCCAAGGGTG
TTACCCTAGAAACAAAGTCAGCAAACGAGTTGTGGTCTAAGGTGGAACAAATTCCTGTAACAGGCATGAAAGCCGGTATC
TATTTACTAGGTCAAGCTAAAAAAGCAGAGACTGGTCAAACTTATTCCGGAGAAATCATTTACAAGGATGCCGCTGCGGT
ATTTCAAAAAACCAAAAACGGGCTTGTCAGGCACAATGCAACACATAACGAAGAAAGACTGGCCAAATTGGTTGAGATAG
GGCAGAACGTTTCTATCGGAAGCAATAAGGGCAAATTGATTGTCAAGTCTTTGGAGTATTCCGCCAAAAAATCCATCAGC
AGATAA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6211.75 Da        Isoelectric Point: 3.6836

>AT211886 WP_015900820.1 NZ_CP080458:c2552094-2551927 [Staphylococcus carnosus]
MSTFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFSVECEACDCNESYLAFDKDE

Download         Length: 168 bp

>AT211886 NZ_CP106822:17259-17690 [Neisseria gonorrhoeae]
ATGAAAGAAAAAATGCGGTTGATCACGGAAATTTCGCTGATTATCAGGGAACTGTCTTATTCCCGGCGCGGGTATCGGCC
TGAGAGTTATGCGGCTGCGCTGGATAATTTGACGATAATCGGAGATTTGGCCGACATTTTGCACAACATCGAGGCAGCGA
CAGGCAATCCATTTGTTCAAAGGATGGTTGATGAAAAACTGAGAAAGTTTGTTACCGATTTTCCGGCTTATAAGGTACGG
TTGTCTCCGTTTTTGAATGGCTGTCCCCATGACCTTTCGTTAGGAGCAGAATCGTTGGGTAAGGGGGAGAGTATCGCTGA
TGCCTTGGCCGTTCCTCCGGAAGAGGTAGATATTGCAGACATTGAGTTTGACCGTGTGCTTATCGAAGACGACCGTTGGA
CAGGAGCATATGATGGTGGTAACGCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G4R0E2

Antitoxin

Source ID Structure
AlphaFold DB A0A380F5Y4

References