Detailed information of TA system TA211884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2118764..2119559
• Replicon: chromosome
• Accession: NZ_CP080457
• Organism: Staphylococcus hominis subsp. hominis strain WiKim0113

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: Sta0113_RS10310
• Protein ID: WP_249339582.1
• Coordinates: 2118764..2118937 (-)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: Sta0113_RS10315
• Protein ID: WP_248855233.1
• Coordinates: 2118960..2119559 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Sta0113_RS10285 (Sta0113_10220)	2113948..2114571	-	624	WP_017176394.1	response regulator transcription factor	-
Sta0113_RS10290 (Sta0113_10225)	2114586..2115695	-	1110	WP_248855232.1	GAF domain-containing sensor histidine kinase	-
Sta0113_RS10295 (Sta0113_10230)	2115833..2116657	+	825	WP_019835689.1	RluA family pseudouridine synthase	-
Sta0113_RS10300 (Sta0113_10235)	2116736..2118121	-	1386	WP_017176397.1	class II fumarate hydratase	-
Sta0113_RS10305 (Sta0113_10240)	2118261..2118653	-	393	WP_017176398.1	hypothetical protein	-
Sta0113_RS10310 (Sta0113_10245)	2118764..2118937	-	174	WP_249339582.1	SAS053 family protein	Toxin
Sta0113_RS10315 (Sta0113_10250)	2118960..2119559	-	600	WP_248855233.1	glucosamine-6-phosphate isomerase	Antitoxin
Sta0113_RS10320 (Sta0113_10255)	2119719..2120189	-	471	WP_017176401.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
Sta0113_RS10325 (Sta0113_10260)	2120192..2121313	-	1122	WP_019835688.1	tRNA epoxyqueuosine(34) reductase QueG	-
Sta0113_RS10330 (Sta0113_10265)	2121390..2123069	-	1680	WP_248855235.1	IS1182 family transposase	-
Sta0113_RS10335 (Sta0113_10270)	2123478..2124200	-	723	WP_017176403.1	amino acid ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2121390..2123069	1679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6739.15 Da
• Isoelectric Point: 3.9837

>T211884 WP_249339582.1 NZ_CP080457:c2118937-2118764 [Staphylococcus hominis subsp. hominis]
IFMSKDSKRNYHEDENAMVQNMDDLEALGKEMEQISEENDEDKYNQTHDSEARSDLN

Nucleotide

• Length: 174 bp

>T211884 NZ_CP106821:c950749-950330 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22389.29 Da
• Isoelectric Point: 5.1379

>AT211884 WP_248855233.1 NZ_CP080457:c2119559-2118960 [Staphylococcus hominis subsp. hominis]
MAMNFKVFEDKQHAADYAGDIIRKQFNNNPTTIAGFHLKKDSAPVLDELKKSVDRNAVDFSQINILDYDDNHSFYEALGV
PSEQVYSISLDDDAESLINDRIKTKENKGKLTLQVVSIDNSGHLDVNIRQGLMKAREIILVVTGAEKSEVIKRLYEENGK
SNFLPADLKVHRMVTVVLDRAAADGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT211884 NZ_CP106821:c950985-950749 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA