Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1249399..1249867 | Replicon | chromosome |
| Accession | NZ_CP080457 | ||
| Organism | Staphylococcus hominis subsp. hominis strain WiKim0113 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | A0A4Q9WRX6 |
| Locus tag | Sta0113_RS06070 | Protein ID | WP_017175887.1 |
| Coordinates | 1249399..1249587 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | A0A4Q9WS45 |
| Locus tag | Sta0113_RS06075 | Protein ID | WP_017175886.1 |
| Coordinates | 1249610..1249867 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Sta0113_RS06035 (Sta0113_05985) | 1245027..1245968 | + | 942 | WP_101804208.1 | cation diffusion facilitator family transporter | - |
| Sta0113_RS06040 (Sta0113_05990) | 1246023..1246199 | - | 177 | WP_019835718.1 | hypothetical protein | - |
| Sta0113_RS06045 (Sta0113_05995) | 1246335..1247039 | - | 705 | WP_017175892.1 | hypothetical protein | - |
| Sta0113_RS06050 (Sta0113_06000) | 1247172..1247399 | - | 228 | WP_019835716.1 | hypothetical protein | - |
| Sta0113_RS06055 (Sta0113_06005) | 1247555..1247839 | - | 285 | WP_019835715.1 | hypothetical protein | - |
| Sta0113_RS06060 (Sta0113_06010) | 1247916..1248662 | - | 747 | WP_049379259.1 | poly-gamma-glutamate hydrolase family protein | - |
| Sta0113_RS06065 (Sta0113_06015) | 1248736..1249230 | - | 495 | WP_231103779.1 | lipoprotein N-acylation protein LnsA | - |
| Sta0113_RS06070 (Sta0113_06020) | 1249399..1249587 | - | 189 | WP_017175887.1 | hypothetical protein | Toxin |
| Sta0113_RS06075 | 1249610..1249867 | - | 258 | WP_017175886.1 | hypothetical protein | Antitoxin |
| Sta0113_RS06080 (Sta0113_06025) | 1250320..1250523 | + | 204 | WP_017175885.1 | sterile alpha motif-like domain-containing protein | - |
| Sta0113_RS06085 (Sta0113_06030) | 1250515..1250757 | - | 243 | WP_017175884.1 | hypothetical protein | - |
| Sta0113_RS06090 (Sta0113_06035) | 1250952..1251551 | + | 600 | WP_019835711.1 | histidine phosphatase family protein | - |
| Sta0113_RS06095 (Sta0113_06040) | 1251566..1252057 | - | 492 | WP_048761455.1 | GNAT family N-acetyltransferase | - |
| Sta0113_RS06100 (Sta0113_06045) | 1252504..1252926 | - | 423 | WP_002448074.1 | organic hydroperoxide resistance protein | - |
| Sta0113_RS06105 (Sta0113_06050) | 1253088..1253813 | + | 726 | WP_048761457.1 | type I 3-dehydroquinate dehydratase | - |
| Sta0113_RS06110 (Sta0113_06055) | 1253883..1254422 | + | 540 | WP_002448165.1 | nitroreductase | - |
| Sta0113_RS06115 (Sta0113_06060) | 1254460..1254783 | - | 324 | WP_048682682.1 | thioredoxin family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | SCCmec | - | clpP | 1176657..1566806 | 390149 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7050.70 Da Isoelectric Point: 9.6269
>T211883 WP_017175887.1 NZ_CP080457:c1249587-1249399 [Staphylococcus hominis subsp. hominis]
MSTHLTILLWLGIIFVVAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVLIFGIL
MSTHLTILLWLGIIFVVAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVLIFGIL
Download Length: 189 bp
>T211883 NZ_CP106820:1597-1875 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10069.23 Da Isoelectric Point: 4.4986
>AT211883 WP_017175886.1 NZ_CP080457:c1249867-1249610 [Staphylococcus hominis subsp. hominis]
MNINKLFWINIMITLLFLGFNITVTYFPKLDDYFWLIPGLIICGLTISFSLIAAILDKNLISEIIFLTNLIIFLYYIYPL
IYNFF
MNINKLFWINIMITLLFLGFNITVTYFPKLDDYFWLIPGLIICGLTISFSLIAAILDKNLISEIIFLTNLIIFLYYIYPL
IYNFF
Download Length: 258 bp
>AT211883 NZ_CP106820:1412-1597 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4Q9WRX6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4Q9WS45 |