Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 23389..23907 Replicon chromosome
Accession NZ_CP080457
Organism Staphylococcus hominis subsp. hominis strain WiKim0113

Toxin (Protein)


Gene name TsdT Uniprot ID A0A1K1Z7E3
Locus tag Sta0113_RS00125 Protein ID WP_048787783.1
Coordinates 23389..23598 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1L8Y5R0
Locus tag Sta0113_RS00130 Protein ID WP_002437530.1
Coordinates 23614..23907 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Sta0113_RS00105 (Sta0113_00105) 18977..20332 - 1356 WP_017174791.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
Sta0113_RS00110 (Sta0113_00110) 20348..21418 - 1071 WP_017174790.1 D-alanine--D-alanine ligase -
Sta0113_RS00115 (Sta0113_00115) 21794..22978 + 1185 WP_048787782.1 FtsW/RodA/SpoVE family cell cycle protein -
Sta0113_RS00120 (Sta0113_00120) 23139..23276 - 138 WP_002437525.1 Lmo0850 family protein -
Sta0113_RS00125 (Sta0113_00125) 23389..23598 - 210 WP_048787783.1 heavy metal-associated domain-containing protein Toxin
Sta0113_RS00130 (Sta0113_00130) 23614..23907 - 294 WP_002437530.1 copper-sensing transcriptional repressor CsoR Antitoxin
Sta0113_RS00135 (Sta0113_00135) 24073..25557 + 1485 WP_145420309.1 cardiolipin synthase -
Sta0113_RS00140 (Sta0113_00140) 25592..26239 + 648 WP_002448635.1 HD domain-containing protein -
Sta0113_RS00145 (Sta0113_00145) 26297..27166 - 870 WP_002455066.1 membrane protein insertase YidC -
Sta0113_RS00150 (Sta0113_00150) 27255..27893 - 639 WP_048787784.1 thiamine phosphate synthase -
Sta0113_RS00155 (Sta0113_00155) 27896..28684 - 789 WP_017175143.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(8-66)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7941.98 Da        Isoelectric Point: 4.0857

>T211882 WP_048787783.1 NZ_CP080457:c23598-23389 [Staphylococcus hominis subsp. hominis]
MLNSNIVFIDNIETEEQAQMLNERLLNMIGVHTVSIDIERNKVNVEYETPTNLNSIEKEIYDAGFKVLS

Download         Length: 210 bp

>T211882 NZ_CP106819:c1631538-1631356 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.84 Da        Isoelectric Point: 6.3270

>AT211882 WP_002437530.1 NZ_CP080457:c23907-23614 [Staphylococcus hominis subsp. hominis]
MENQNHAHHSEQVKLNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLEHHMKSCIMEKINQGTE
EEAMEELLVTFQKLVKD

Download         Length: 294 bp

>AT211882 NZ_CP106819:c1631254-1630853 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1K1Z7E3

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5R0

References