Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3558543..3559196 Replicon chromosome
Accession NZ_CP080452
Organism Acinetobacter baumannii strain MRSN 56

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag FBMFHHBO_RS17020 Protein ID WP_000931890.1
Coordinates 3558543..3558932 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag FBMFHHBO_RS17025 Protein ID WP_001288210.1
Coordinates 3558939..3559196 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBMFHHBO_RS17005 (FBMFHHBO_17005) 3553661..3555856 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
FBMFHHBO_RS17010 (FBMFHHBO_17010) 3556044..3556610 - 567 WP_000651536.1 rhombosortase -
FBMFHHBO_RS17015 (FBMFHHBO_17015) 3556688..3557773 - 1086 WP_000049106.1 hypothetical protein -
FBMFHHBO_RS17020 (FBMFHHBO_17020) 3558543..3558932 - 390 WP_000931890.1 membrane protein Toxin
FBMFHHBO_RS17025 (FBMFHHBO_17025) 3558939..3559196 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
FBMFHHBO_RS17030 (FBMFHHBO_17030) 3559384..3560556 + 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
FBMFHHBO_RS17035 (FBMFHHBO_17035) 3560606..3562096 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
FBMFHHBO_RS17040 (FBMFHHBO_17040) 3562277..3562654 - 378 WP_001216380.1 50S ribosomal protein L17 -
FBMFHHBO_RS17045 (FBMFHHBO_17045) 3562673..3563680 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T211879 WP_000931890.1 NZ_CP080452:c3558932-3558543 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T211879 NZ_CP106817:c1635581-1635399 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGTCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT211879 WP_001288210.1 NZ_CP080452:c3559196-3558939 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT211879 NZ_CP106817:c1635297-1634896 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References