Detailed information of TA system TA211878

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pmenTA/darT(toxin)
• Location: 1241899..1243640
• Replicon: chromosome
• Accession: NZ_CP080452
• Organism: Acinetobacter baumannii strain MRSN 56

Toxin (Protein)

• Gene name: pmenT
• Uniprot ID: N9S537
• Locus tag: FBMFHHBO_RS05990
• Protein ID: WP_000233088.1
• Coordinates: 1241899..1242555 (+)
• Length: 219 a.a.

Antitoxin (Protein)

• Gene name: pmenA
• Uniprot ID: -
• Locus tag: FBMFHHBO_RS05995
• Protein ID: WP_003112112.1
• Coordinates: 1242555..1243640 (+)
• Length: 362 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FBMFHHBO_RS05980 (FBMFHHBO_05980)	1237054..1238424	+	1371	WP_003114524.1	EH signature domain-containing protein	-
FBMFHHBO_RS05985 (FBMFHHBO_05985)	1238457..1241660	+	3204	WP_003129329.1	DEAD/DEAH box helicase	-
FBMFHHBO_RS05990 (FBMFHHBO_05990)	1241899..1242555	+	657	WP_000233088.1	DUF4433 domain-containing protein	Toxin
FBMFHHBO_RS05995 (FBMFHHBO_05995)	1242555..1243640	+	1086	WP_003112112.1	macro domain-containing protein	Antitoxin
FBMFHHBO_RS19635	1243679..1243807	+	129	WP_005135528.1	hypothetical protein	-
FBMFHHBO_RS06000 (FBMFHHBO_06000)	1244428..1245309	+	882	WP_000732866.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
FBMFHHBO_RS06005 (FBMFHHBO_06005)	1245434..1245700	-	267	WP_000703423.1	hypothetical protein	-
FBMFHHBO_RS06010 (FBMFHHBO_06010)	1246364..1246918	+	555	WP_002024621.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ssDNA thymidine ADP-ribosyltransferase, DarT (18-218)

Antitoxin

• Macro domain (18-129)

Sequences

Toxin

Protein

• Length: 219 a.a.
• Molecular weight: 25316.92 Da
• Isoelectric Point: 7.1033

>T211878 WP_000233088.1 NZ_CP080452:1241899-1242555 [Acinetobacter baumannii]
MVGRNYSDVLNPQKALIWRIVHRDNIPWILENGLHSSNSPTQCVNWVQIGSPELIEKRQLHPVPVGKKGVLSDYIPFYFT
PFSPMLLNIKSGRGGVRQRTNDEIVILVSSLYQLQQQQIPFVFTNSHAYYQWAEFYTDLSSLNEIDWSILQARDFKRDMD
DPAKFERYQAEALVHQHCPTKVLIGVICYTETVKAQIEQWLQQADVNIPVHVRQGVYF

Nucleotide

• Length: 657 bp

>T211878 NZ_CP106817:651859-652278 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGTGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Protein

• Length: 362 a.a.
• Molecular weight: 41063.20 Da
• Isoelectric Point: 6.0689

>AT211878 WP_003112112.1 NZ_CP080452:1242555-1243640 [Acinetobacter baumannii]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPKNMAAYSQACKAGQVTTGKMFVTETNELMGARWIINFPTK
QHWRDKSKLQWIEDGLQDLKKFIIDHQVKSIAIPPLGAGNGGLEWSRVKSKIETELSDLEYVDILIFEPTTQYQNVAKKI
GVSQLTPARAMIAELVRRYWVLGIECSLLEIQKLAWFLQRVIEQKQLPNELKLNFQANYYGPYASNLDHLLNAMDGSYLK
SDKRIPDCDPLDVIWFNDQQKSKVQGYLISEAKEYMAAVEGAATLIEGFESPFGMELLATVDWLIYKEGYQPNVESIQEG
LANWSAGERWARRKSDLFKAEHIQFALQKLDGFAYFHTDVT

Nucleotide

• Length: 1086 bp

>AT211878 NZ_CP106817:651623-651859 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Structures

Toxin

• AlphaFold DB: N9S537