211876

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 535755..537295 Replicon chromosome
Accession NZ_CP080422
Organism Shewanella alkalitolerans strain FJAT-54031

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K0J45_RS02450 Protein ID WP_220044103.1
Coordinates 535994..537295 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K0J45_RS02445 Protein ID WP_220044101.1
Coordinates 535755..535991 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0J45_RS19725 532213..532440 - 228 WP_258406749.1 hypothetical protein -
K0J45_RS02430 (K0J45_02430) 532442..533422 - 981 WP_220044098.1 GAF domain-containing protein -
K0J45_RS02435 (K0J45_02435) 533705..534502 - 798 WP_220044099.1 NYN domain-containing protein -
K0J45_RS02440 (K0J45_02440) 534533..534907 - 375 WP_220044100.1 molecular chaperone DnaJ -
K0J45_RS02445 (K0J45_02445) 535755..535991 + 237 WP_220044101.1 helix-turn-helix domain-containing protein Antitoxin
K0J45_RS02450 (K0J45_02450) 535994..537295 + 1302 WP_220044103.1 HipA domain-containing protein Toxin
K0J45_RS02455 (K0J45_02455) 537383..538471 + 1089 WP_220044104.1 hypothetical protein -
K0J45_RS02460 (K0J45_02460) 538607..539011 + 405 WP_220044105.1 hypothetical protein -
K0J45_RS02465 (K0J45_02465) 539286..539930 - 645 WP_220044106.1 lipoprotein -
K0J45_RS02470 (K0J45_02470) 540390..541556 + 1167 WP_220044107.1 BamA/TamA family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48428.36 Da        Isoelectric Point: 4.6419

>T211876 WP_220044103.1 NZ_CP080422:535994-537295 [Shewanella alkalitolerans]
MAESPILVLDMLLGDQLIGALSFDPSDERFAVSYTQAWQQSGFPLSPMIPLDGSGSSTQIAMFLVNLLPENKGLDYLVES
LGVAKGNTFALIRAIGLDTAGAIAFSSKGSAFPPTRFRTISDDEIVQRLEDPEFWPMEVWDGRPRLSVAGVQSKLNLFFN
GEEFGFGEGALSSTHILKFEQHPHLVINEFLTMRLAKALALNVANVEIRCFGQYKSLCVERFDRRYLADENRVQRRHIID
SCQALGFSVNKKYERNFGSGRDVRDIREGVSLPRLFGLANQCINPAAAKQDMLRWTLFNLLSGNADAHGKNYSFFMTPKG
MSPTPWYDLVCVALYEDFEQELAMAIDDEFDPNKIYAYQLAAFSEEVGLPRALIVNSLDKMVAKIRLEINGVIAMLNDLD
EDEQAFVEAYKAQLLARCERYSAIAPDIKAIEL

Download         Length: 1302 bp

>T211876 NZ_CP106815:c1641069-1640887 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGTCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8534.89 Da        Isoelectric Point: 7.9713

>AT211876 WP_220044101.1 NZ_CP080422:535755-535991 [Shewanella alkalitolerans]
MSSSLNQDSLGLLIKTRRKEAALTQEVAAMLCGVTKKTLIRVEKGEDVYISTLFKILDGLGIRLAVESKSDAGSSEWY

Download         Length: 237 bp

>AT211876 NZ_CP106815:c1640785-1640384 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References