Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 547393..548934 Replicon chromosome
Accession NZ_CP080419
Organism Shewanella psychrotolerans strain FJAT-53749

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K0I62_RS02485 Protein ID WP_220069976.1
Coordinates 547633..548934 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K0I62_RS02480 Protein ID WP_220069975.1
Coordinates 547393..547629 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0I62_RS02465 (K0I62_02465) 542704..542994 + 291 WP_220062912.1 co-chaperone GroES -
K0I62_RS02470 (K0I62_02470) 543051..544700 + 1650 WP_220069973.1 chaperonin GroEL -
K0I62_RS02475 (K0I62_02475) 545229..546833 + 1605 WP_220069974.1 RICIN domain-containing protein -
K0I62_RS02480 (K0I62_02480) 547393..547629 + 237 WP_220069975.1 helix-turn-helix domain-containing protein Antitoxin
K0I62_RS02485 (K0I62_02485) 547633..548934 + 1302 WP_220069976.1 HipA domain-containing protein Toxin
K0I62_RS02490 (K0I62_02490) 549225..549479 + 255 WP_220069977.1 hypothetical protein -
K0I62_RS02495 (K0I62_02495) 550096..550500 + 405 WP_220069978.1 hypothetical protein -
K0I62_RS02500 (K0I62_02500) 550807..551970 + 1164 WP_220069979.1 BamA/TamA family outer membrane protein -
K0I62_RS02505 (K0I62_02505) 552105..552785 + 681 WP_220071256.1 hypothetical protein -
K0I62_RS02510 (K0I62_02510) 553010..553648 + 639 WP_220069980.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48437.49 Da        Isoelectric Point: 4.7844

>T211873 WP_220069976.1 NZ_CP080419:547633-548934 [Shewanella psychrotolerans]
MTDSVKLVLDMHLGDRIIGELSFDPDIEKFAVSYTDIWQQNGFPISPMIPLDGSGRSNQIAMFLVNLLPENKGLDYLVES
LGVSRGNTFALIRGIGLDTAGAIAFVPKGVLLPGTSFRAISDDEVIKRLEDPDIWPMEVWDGKPRLSVAGVQSKLNLFYN
GEAFGFAEGALSSTHILKFEKHQHLVINEFLTMRLANAISMNVANVDISYFGEHKALCVERFDRRYLPAEHKVQRRHIID
SCQTLGFSVNKKYERNFGTGRDVKDIREGVSFARLFSLASQCANPAAAKQDMLQWALFNLLSGNADAHGKNYSFFMTPTG
LAPTPWYDLVCVALYDDFEQELAMAIDDEFDPNKIYAYQLAAFIDEIGLPRALLVNNLTQMATKIAQAIDEVTAMLPALD
KAEQDFVDAYRKQLLARCERYLAMAPEIKDIEL

Download         Length: 1302 bp

>T211873 NZ_CP106813:c1643356-1643174 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8408.74 Da        Isoelectric Point: 9.9753

>AT211873 WP_220069975.1 NZ_CP080419:547393-547629 [Shewanella psychrotolerans]
MKSSLNQQSLGSLVKESRKKAGLTQEVAAMLCGVTKKTFIRVEKGEDVYISTVFKILDGLGVAIVAKQDNSANASGWY

Download         Length: 237 bp

>AT211873 NZ_CP106813:c1643072-1642671 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References