Detailed information of TA system TA211871

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 529328..530868
• Replicon: chromosome
• Accession: NZ_CP080418
• Organism: Shewanella spartinae strain FJAT-53681

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K0I31_RS02425
• Protein ID: WP_220079773.1
• Coordinates: 529567..530868 (+)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K0I31_RS02420
• Protein ID: WP_011864284.1
• Coordinates: 529328..529564 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0I31_RS02415 (K0I31_02415)	525817..528870	+	3054	WP_220079772.1	DEAD/DEAH box helicase family protein	-
K0I31_RS02420 (K0I31_02420)	529328..529564	+	237	WP_011864284.1	helix-turn-helix domain-containing protein	Antitoxin
K0I31_RS02425 (K0I31_02425)	529567..530868	+	1302	WP_220079773.1	HipA domain-containing protein	Toxin
K0I31_RS02430 (K0I31_02430)	530956..531996	+	1041	WP_220079774.1	tetratricopeptide repeat protein	-
K0I31_RS02435 (K0I31_02435)	532132..532536	+	405	WP_011864287.1	hypothetical protein	-
K0I31_RS02440 (K0I31_02440)	532826..533992	+	1167	WP_220079775.1	BamA/TamA family outer membrane protein	-
K0I31_RS02445 (K0I31_02445)	533995..534807	+	813	WP_220079776.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-65)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48429.39 Da
• Isoelectric Point: 4.5984

>T211871 WP_220079773.1 NZ_CP080418:529567-530868 [Shewanella spartinae]
MAESPILVLDMLLGDQLIGALSFNPSDERFAVSYTQAWQQSGFPLSPMVPLDGSGSSTQIAMFLVNLLPENKGLDYLVES
LGVAKGNTFALIRAIGLDTAGAIAFSSNGSAFPPTTFRTISDDEIVQRLEDPEFWPMEIWDGRPRLSVAGVQSKLNLFFN
GEEFGFGEGALSSTHILKFEQHPHLVINEFLTMRLAKALALNVANVEIRCFGQYKSLCVERFDRRYLADENRVQRRHIID
SCQALGFSVNKKYERNFGSGRDVRDIREGVSLPRLFGLANQCINPAAAKQDMLRWTLFNLLSGNADAHGKNYSFFMTPKG
MSPTPWYDLVCVALYEDFEQELAMAIDDEFDPNKIYAYQLAAFSEEVGLPRALIVNSLDKMLVKIRLEIDGVIAMLKDLD
EDEQAFVEAYKAQLLARCERYSAIAPEIKAIEL

Nucleotide

• Length: 1302 bp

>T211871 NZ_CP106812:2395-2673 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8520.86 Da
• Isoelectric Point: 7.9713

>AT211871 WP_011864284.1 NZ_CP080418:529328-529564 [Shewanella spartinae]
MSSSLNQDSLGLLIKTRRKEAALTQEVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIRLAVESKSDAGSSEWY

Nucleotide

• Length: 237 bp

>AT211871 NZ_CP106812:2210-2395 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA