Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3532822..3534363 Replicon chromosome
Accession NZ_CP080413
Organism Shewanella acanthi strain FJAT-51860

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K0H61_RS15110 Protein ID WP_258405961.1
Coordinates 3532822..3534123 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K0H61_RS15115 Protein ID WP_220050306.1
Coordinates 3534127..3534363 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0H61_RS15095 (K0H61_15095) 3528408..3529925 - 1518 WP_220050303.1 arylsulfatase -
K0H61_RS15100 (K0H61_15100) 3530198..3531715 - 1518 WP_220050304.1 arylsulfatase -
K0H61_RS15105 (K0H61_15105) 3531858..3532706 + 849 WP_220050305.1 LysR family transcriptional regulator -
K0H61_RS15110 (K0H61_15110) 3532822..3534123 - 1302 WP_258405961.1 HipA domain-containing protein Toxin
K0H61_RS15115 (K0H61_15115) 3534127..3534363 - 237 WP_220050306.1 helix-turn-helix transcriptional regulator Antitoxin
K0H61_RS15120 (K0H61_15120) 3534968..3535936 - 969 WP_220050307.1 nuclease-related domain-containing protein -
K0H61_RS15125 (K0H61_15125) 3536589..3538226 - 1638 WP_220050308.1 chaperonin GroEL -
K0H61_RS15130 (K0H61_15130) 3538274..3538564 - 291 WP_220050309.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(146-386)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-63)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48461.75 Da        Isoelectric Point: 4.9746

>T211866 WP_258405961.1 NZ_CP080413:c3534123-3532822 [Shewanella acanthi]
MNNPTMLTLEMYLGDLLIGELSFDSATDTFAVQYTDKWQQIGFPISPMLPLDGSGSSNQISMFLVNLLPENRGLDYLIES
LGVSRGNTFALIRAIGLDTAGAVAFVPKGTQLPATHLRPIAESEIIQRIEDPDIWPMEVWDGKPRLSVAGVQPKLNLFDD
GKVFAFAEGGLSSTHILKFEKFRHLVINEFMTMRLAKAIGMNVAHVDIVQFGHHKVLSVTRFDRVYRQDEGRVLRRHIVD
CCQALGFSVSKKYERNFGSGRDVKNIREGVSFNRLFSLAGQCSNPVAAKQDMLQWALFNLLSGNADAHGKNYSFFMLPKG
MEPTPWYDLVNVAMYPEFEQELAMAIDDEFDPNKIFAYQLGAFAEDLGLPRNLLISNLTKLASKIPQVLDEVISMLPALD
DAETAFVAQYKESLLARCDYYLGIVKEVKDIEV

Download         Length: 1302 bp

>T211866 NZ_CP106809:661525-661944 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8568.95 Da        Isoelectric Point: 9.0285

>AT211866 WP_220050306.1 NZ_CP080413:c3534363-3534127 [Shewanella acanthi]
MSSPLNQQSLGLLIKERRKQASLTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKIINGLGINIISEQTSALDANGWY

Download         Length: 237 bp

>AT211866 NZ_CP106809:661289-661525 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References