Detailed information of TA system TA211864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4375220..4376826
• Replicon: chromosome
• Accession: NZ_CP080412
• Organism: Shewanella mangrovisoli strain FJAT-51754

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K0H60_RS19030
• Protein ID: WP_220056705.1
• Coordinates: 4375220..4376548 (-)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K0H60_RS19035
• Protein ID: WP_220056706.1
• Coordinates: 4376548..4376826 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0H60_RS19000 (K0H60_19000)	4370795..4371448	+	654	WP_220056700.1	hypothetical protein	-
K0H60_RS19005 (K0H60_19005)	4371505..4372155	-	651	WP_220056701.1	HGGxSTG domain-containing protein	-
K0H60_RS19010 (K0H60_19010)	4372526..4373191	-	666	WP_220056702.1	inovirus-type Gp2 protein	-
K0H60_RS19020 (K0H60_19020)	4373620..4373841	-	222	WP_220056703.1	AlpA family phage regulatory protein	-
K0H60_RS19025 (K0H60_19025)	4373949..4374698	-	750	WP_220056704.1	hypothetical protein	-
K0H60_RS19030 (K0H60_19030)	4375220..4376548	-	1329	WP_220056705.1	type II toxin-antitoxin system HipA family toxin	Toxin
K0H60_RS19035 (K0H60_19035)	4376548..4376826	-	279	WP_220056706.1	helix-turn-helix domain-containing protein	Antitoxin
K0H60_RS19040 (K0H60_19040)	4377224..4377940	-	717	WP_220056707.1	pyrimidine 5'-nucleotidase	-
K0H60_RS19045 (K0H60_19045)	4378119..4378580	-	462	WP_220056708.1	DMT family transporter	-
K0H60_RS19050 (K0H60_19050)	4378603..4379094	-	492	WP_220056709.1	DMT family transporter	-
K0H60_RS19055 (K0H60_19055)	4379340..4380227	+	888	WP_220056710.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4365047..4376826	11779

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 48972.95 Da
• Isoelectric Point: 7.4455

>T211864 WP_220056705.1 NZ_CP080412:c4376548-4375220 [Shewanella mangrovisoli]
MAALDVYMNGYLVGEFIKTPTGAHQFKYHEDWLALAGSRPISLSMPLRRQAYIGDEVYNFFDNLLPDNPEVRNRIVARHQ
AASSQPFDLLAKIGQDSVGALQLIPQGELPINVRQIDAKPLSSAELEKVLKGYLSGIPLGMLREQDDFRISIAGAQEKTA
LLNIDGKWCLPLHATPTTHIIKLPIGTIKGHSFDIDMSDSVENEYLCMKIAKAFGLAVAGCNIMKVGDIKALVVERFDRR
LASDGSWLMRLPQEDFCQVLNVPPAKKYESDGGPGIQAIMAQLLGSAMPERDRYDFMKAQVLFWLLGAIDGHAKNFSIFI
DAGGGYRLTPLYDILSIYPALGGKGPNIRDVKLAMALKGSKGKKVLLESIFPRHFIQTAKTVGFDTDSMVGIMTEMADML
DFVIMKVSRELPDDFPVQIRDSIISGLKKRAQRLGIENLTRF

Nucleotide

• Length: 1329 bp

>T211864 NZ_CP106807:c1643397-1643215 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10497.95 Da
• Isoelectric Point: 9.6559

>AT211864 WP_220056706.1 NZ_CP080412:c4376826-4376548 [Shewanella mangrovisoli]
MKVTTAKQLSNYLKDTRLSLKLSQSKVANKVGIRQDTVSSFEQNPDSTKLETLFKLLASLNLELEVKKRGVSIDNIRLDN
TSLDGQDWKEEW

Nucleotide

• Length: 279 bp

>AT211864 NZ_CP106807:c1643113-1642712 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG