Detailed information of TA system TA211860

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4518817..4520075
• Replicon: chromosome
• Accession: NZ_CP080405
• Organism: Pseudomonas aeruginosa strain PES_P749

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: K0T28_RS20835
• Protein ID: WP_023084533.1
• Coordinates: 4518817..4519572 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: K0T28_RS20840
• Protein ID: WP_003086329.1
• Coordinates: 4519707..4520075 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0T28_RS20825 (K0T28_20815)	4513990..4516533	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
K0T28_RS20830 (K0T28_20820)	4516688..4518049	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
K0T28_RS20835 (K0T28_20825)	4518817..4519572	-	756	WP_023084533.1	RES family NAD+ phosphorylase	Toxin
K0T28_RS20840 (K0T28_20830)	4519707..4520075	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
K0T28_RS20845 (K0T28_20835)	4520148..4521434	-	1287	WP_003112529.1	FAD-binding oxidoreductase	-
K0T28_RS20850 (K0T28_20840)	4521490..4522983	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
K0T28_RS20855 (K0T28_20845)	4523158..4523634	+	477	WP_003112531.1	hypothetical protein	-
K0T28_RS20860 (K0T28_20850)	4523637..4523912	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28282.43 Da
• Isoelectric Point: 7.7294

>T211860 WP_023084533.1 NZ_CP080405:c4519572-4518817 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T211860 NZ_CP106805:c948381-947962 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT211860 WP_003086329.1 NZ_CP080405:c4520075-4519707 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT211860 NZ_CP106805:c948617-948381 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7