Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3560539..3561760 Replicon chromosome
Accession NZ_CP080405
Organism Pseudomonas aeruginosa strain PES_P749

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K0T28_RS16325 Protein ID WP_003114949.1
Coordinates 3561182..3561760 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K0T28_RS16320 Protein ID WP_003088112.1
Coordinates 3560539..3561093 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0T28_RS16295 (K0T28_16285) 3556107..3556658 + 552 WP_003102727.1 XRE family transcriptional regulator -
K0T28_RS16300 (K0T28_16290) 3556655..3557053 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
K0T28_RS16305 (K0T28_16295) 3557066..3557389 - 324 WP_003102734.1 multidrug efflux SMR transporter -
K0T28_RS16310 (K0T28_16300) 3557720..3558181 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
K0T28_RS16315 (K0T28_16305) 3558186..3560381 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
K0T28_RS16320 (K0T28_16310) 3560539..3561093 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
K0T28_RS16325 (K0T28_16315) 3561182..3561760 + 579 WP_003114949.1 HD domain-containing protein Toxin
K0T28_RS16330 (K0T28_16320) 3561868..3563055 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
K0T28_RS16335 (K0T28_16325) 3563045..3565216 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
K0T28_RS16340 (K0T28_16330) 3565206..3566483 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T211859 WP_003114949.1 NZ_CP080405:3561182-3561760 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T211859 NZ_CP106804:2921-3199 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT211859 WP_003088112.1 NZ_CP080405:3560539-3561093 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT211859 NZ_CP106804:2736-2921 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References