Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141658..142163 Replicon chromosome
Accession NZ_CP080405
Organism Pseudomonas aeruginosa strain PES_P749

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag K0T28_RS00645 Protein ID WP_003083773.1
Coordinates 141658..141939 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag K0T28_RS00650 Protein ID WP_003083775.1
Coordinates 141936..142163 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0T28_RS00620 (K0T28_00620) 136909..138258 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
K0T28_RS00625 (K0T28_00625) 138307..138993 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
K0T28_RS00630 (K0T28_00630) 139094..139828 + 735 WP_023119575.1 GntR family transcriptional regulator -
K0T28_RS00635 (K0T28_00635) 140008..140418 + 411 WP_003110659.1 aegerolysin family protein -
K0T28_RS00640 (K0T28_00640) 140450..141358 - 909 WP_003083769.1 LysR family transcriptional regulator -
K0T28_RS00645 (K0T28_00645) 141658..141939 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
K0T28_RS00650 (K0T28_00650) 141936..142163 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
K0T28_RS00655 (K0T28_00655) 142338..142958 - 621 WP_003101226.1 hypothetical protein -
K0T28_RS00660 (K0T28_00660) 143059..143559 + 501 WP_003162763.1 LEA type 2 family protein -
K0T28_RS00665 (K0T28_00665) 143632..143973 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
K0T28_RS00670 (K0T28_00670) 144055..145482 - 1428 WP_003083784.1 GABA permease -
K0T28_RS00675 (K0T28_00675) 145651..147144 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T211856 WP_003083773.1 NZ_CP080405:c141939-141658 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T211856 NZ_CP106802:3120-3398 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT211856 WP_003083775.1 NZ_CP080405:c142163-141936 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT211856 NZ_CP106802:2935-3120 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References