Detailed information of TA system TA211845

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1689337..1689890
• Replicon: chromosome
• Accession: NZ_CP080400
• Organism: Dickeya fangzhongdai strain Onc5

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: K0H75_RS07405
• Protein ID: WP_038900914.1
• Coordinates: 1689576..1689890 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: K0H75_RS07400
• Protein ID: WP_038918488.1
• Coordinates: 1689337..1689573 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0H75_RS07385 (K0H75_07380)	1684785..1686020	-	1236	WP_038918486.1	DNA cytosine methyltransferase	-
K0H75_RS07390 (K0H75_07385)	1686305..1687327	+	1023	WP_038920880.1	DUF4917 family protein	-
K0H75_RS07395 (K0H75_07390)	1688072..1689016	+	945	WP_038918487.1	zincin-like metallopeptidase domain-containing protein	-
K0H75_RS07400 (K0H75_07395)	1689337..1689573	+	237	WP_038918488.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
K0H75_RS07405 (K0H75_07400)	1689576..1689890	+	315	WP_038900914.1	CcdB family protein	Toxin
K0H75_RS07410	1689887..1690009	-	123	Protein_1442	mobilization protein mobC	-
K0H75_RS07415 (K0H75_07405)	1690213..1691865	+	1653	WP_038918489.1	hypothetical protein	-
K0H75_RS07420 (K0H75_07410)	1691865..1693355	+	1491	WP_038918490.1	hypothetical protein	-
K0H75_RS07425 (K0H75_07415)	1693627..1694736	-	1110	WP_198677320.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1655915..1697469	41554

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11473.41 Da
• Isoelectric Point: 7.9859

>T211845 WP_038900914.1 NZ_CP080400:1689576-1689890 [Dickeya fangzhongdai]
MQFTVYGNTGKSAIYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI

Nucleotide

• Length: 315 bp

>T211845 NZ_CP106786:c5232421-5232038 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTA
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9008.01 Da
• Isoelectric Point: 6.2206

>AT211845 WP_038918488.1 NZ_CP080400:1689337-1689573 [Dickeya fangzhongdai]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRHHEAKKWQEENREAIDALNRFHDEQGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT211845 NZ_CP106786:c5232663-5232421 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGCCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA