Detailed information of TA system TA211843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1018749..1019275
• Replicon: chromosome
• Accession: NZ_CP080400
• Organism: Dickeya fangzhongdai strain Onc5

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: K0H75_RS04560
• Protein ID: WP_038918043.1
• Coordinates: 1018749..1019054 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: K0H75_RS04565
• Protein ID: WP_038918044.1
• Coordinates: 1019057..1019275 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0H75_RS04550 (K0H75_04550)	1015362..1017371	+	2010	WP_193745938.1	helicase-related protein	-
K0H75_RS04555 (K0H75_04555)	1017373..1018638	+	1266	WP_038918041.1	GIY-YIG nuclease family protein	-
K0H75_RS04560 (K0H75_04560)	1018749..1019054	-	306	WP_038918043.1	type II toxin-antitoxin system toxin CcdB	Toxin
K0H75_RS04565 (K0H75_04565)	1019057..1019275	-	219	WP_038918044.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
K0H75_RS04570 (K0H75_04570)	1019334..1020077	-	744	WP_038918045.1	MobC family replication-relaxation protein	-
K0H75_RS04575 (K0H75_04575)	1020981..1021322	-	342	WP_038918046.1	hypothetical protein	-
K0H75_RS04580 (K0H75_04580)	1021779..1023041	-	1263	WP_038918047.1	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	989621..1021322	31701

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11821.72 Da
• Isoelectric Point: 4.6873

>T211843 WP_038918043.1 NZ_CP080400:c1019054-1018749 [Dickeya fangzhongdai]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIESHHLSEKVNKMLFPLLRIDGEDYRLMTTELSSVPVEVIGEEI
ADLGDYADEIKDAINLMFWGI

Nucleotide

• Length: 306 bp

>T211843 NZ_CP106786:4783034-4783318 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8220.17 Da
• Isoelectric Point: 7.0142

>AT211843 WP_038918044.1 NZ_CP080400:c1019275-1019057 [Dickeya fangzhongdai]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNEAIGKEARRIRAEEWKKENREGMEEVARFIAQNGSFADENRNW

Nucleotide

• Length: 219 bp

>AT211843 NZ_CP106786:4782802-4783044 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA