Detailed information of TA system TA211842

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 714448..715126
• Replicon: chromosome
• Accession: NZ_CP080400
• Organism: Dickeya fangzhongdai strain Onc5

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: K0H75_RS03320
• Protein ID: WP_023637601.1
• Coordinates: 714695..715126 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A2K8QSU7
• Locus tag: K0H75_RS03315
• Protein ID: WP_023637600.1
• Coordinates: 714448..714714 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0H75_RS03295 (K0H75_03295)	710894..711544	+	651	WP_038917839.1	LysE family translocator	-
K0H75_RS03300 (K0H75_03300)	711615..712223	-	609	WP_038917841.1	HD domain-containing protein	-
K0H75_RS03305 (K0H75_03305)	712434..713084	+	651	WP_038917842.1	hemolysin III family protein	-
K0H75_RS03310 (K0H75_03310)	713157..714137	-	981	WP_038917843.1	tRNA-modifying protein YgfZ	-
K0H75_RS03315 (K0H75_03315)	714448..714714	+	267	WP_023637600.1	FAD assembly factor SdhE	Antitoxin
K0H75_RS03320 (K0H75_03320)	714695..715126	+	432	WP_023637601.1	protein YgfX	Toxin
K0H75_RS03325 (K0H75_03325)	715226..715744	-	519	WP_038917844.1	flavodoxin FldB	-
K0H75_RS03330 (K0H75_03330)	715873..717198	-	1326	WP_038662304.1	MFS transporter	-
K0H75_RS03335 (K0H75_03335)	717461..718360	+	900	WP_038917846.1	site-specific tyrosine recombinase XerD	-
K0H75_RS03340 (K0H75_03340)	718449..719165	+	717	WP_038917847.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16808.51 Da
• Isoelectric Point: 11.7737

>T211842 WP_023637601.1 NZ_CP080400:714695-715126 [Dickeya fangzhongdai]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQIARRPWVMRNGVLLSLRATTGKGHQRLWLASDSMGNEEWRLLRQLLQQHPLQGTESSRHH

Nucleotide

• Length: 432 bp

>T211842 NZ_CP106786:c4661135-4660602 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10544.03 Da
• Isoelectric Point: 5.5535

>AT211842 WP_023637600.1 NZ_CP080400:714448-714714 [Dickeya fangzhongdai]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQHFIRLLQCDDPDLFNWLMNHGEPVDPELKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT211842 NZ_CP106786:c4661412-4661146 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2K8QSU7