Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 591238..591832 Replicon chromosome
Accession NZ_CP080387
Organism Agrobacterium cucumeris strain O132

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KZ699_RS02835 Protein ID WP_269698848.1
Coordinates 591518..591832 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KZ699_RS02830 Protein ID WP_269698515.1
Coordinates 591238..591537 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ699_RS02805 (KZ699_02785) 586352..587350 + 999 WP_269698518.1 asparaginase -
KZ699_RS02810 (KZ699_02790) 587512..588135 + 624 WP_142839302.1 glutathione S-transferase family protein -
KZ699_RS02815 (KZ699_02795) 588278..588937 - 660 WP_269698517.1 glutathione S-transferase family protein -
KZ699_RS02820 (KZ699_02800) 589020..589535 - 516 WP_142839304.1 MarR family transcriptional regulator -
KZ699_RS02825 (KZ699_02805) 589677..591206 + 1530 WP_269698516.1 MDR family MFS transporter -
KZ699_RS02830 (KZ699_02810) 591238..591537 - 300 WP_269698515.1 putative addiction module antidote protein Antitoxin
KZ699_RS02835 (KZ699_02815) 591518..591832 - 315 WP_269698848.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZ699_RS02840 (KZ699_02820) 592074..593084 + 1011 WP_269698847.1 ligase-associated DNA damage response exonuclease -
KZ699_RS02845 (KZ699_02825) 593086..594717 + 1632 WP_269698514.1 cisplatin damage response ATP-dependent DNA ligase -
KZ699_RS02850 (KZ699_02830) 595036..596001 + 966 WP_269698513.1 alpha/beta fold hydrolase -
KZ699_RS02855 (KZ699_02835) 596008..596817 - 810 WP_269698512.1 glycosyltransferase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(4-97)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11654.32 Da        Isoelectric Point: 10.3872

>T211838 WP_269698848.1 NZ_CP080387:c591832-591518 [Agrobacterium cucumeris]
INSFEKSAEFDEWLKALKDRTGKVRILHRLTAAEHGNFGDCQPVGEGVSEMRIHFGPGYRVYFTRVGKRIYFLLIGGNKS
SQRRDIKRAIAMAQAIGGDGRDGI

Download         Length: 315 bp

>T211838 NZ_CP106786:2124656-2124758 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10824.36 Da        Isoelectric Point: 4.8307

>AT211838 WP_269698515.1 NZ_CP080387:c591537-591238 [Agrobacterium cucumeris]
MAVTEFSKFDVSDYLDNDETMIEYLAVAMEDENPDVFIAALGAVARARGMSHVADVSGLGRESLYKALKPGSKLRYETVQ
KVLHALGFRLAVEKSLNAA

Download         Length: 300 bp

>AT211838 NZ_CP106786:c2124765-2124620 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References