Detailed information of TA system TA211836

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 2315045..2315541
• Replicon: chromosome
• Accession: NZ_CP080383
• Organism: Cryobacterium sp. PAMC25264

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KY500_RS10685
• Protein ID: WP_219900553.1
• Coordinates: 2315287..2315541 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KY500_RS10680
• Protein ID: WP_219903404.1
• Coordinates: 2315045..2315290 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KY500_RS10670 (KY500_10670)	2312701..2313441	-	741	WP_255579180.1	DUF4194 domain-containing protein	-
KY500_RS10675 (KY500_10675)	2313438..2314889	-	1452	WP_219900552.1	DUF3375 domain-containing protein	-
KY500_RS10680 (KY500_10680)	2315045..2315290	+	246	WP_219903404.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KY500_RS10685 (KY500_10685)	2315287..2315541	+	255	WP_219900553.1	Txe/YoeB family addiction module toxin	Toxin
KY500_RS10690 (KY500_10690)	2315549..2317021	-	1473	WP_219900554.1	peptide MFS transporter	-
KY500_RS10695 (KY500_10695)	2317375..2317710	-	336	WP_219900555.1	hypothetical protein	-
KY500_RS10700 (KY500_10700)	2317739..2317912	-	174	WP_219900556.1	helix-turn-helix transcriptional regulator	-
KY500_RS10705 (KY500_10705)	2317973..2319274	+	1302	WP_219900557.1	hypothetical protein	-
KY500_RS10710 (KY500_10710)	2319489..2319899	-	411	WP_219900558.1	DUF2256 and DUF3253 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9901.29 Da
• Isoelectric Point: 8.4795

>T211836 WP_219900553.1 NZ_CP080383:2315287-2315541 [Cryobacterium sp. PAMC25264]
VIIAFTDAGWDDYQYWVTTDRTMVKRINKLIADVQRTPFTGIGKPEALKHQLAGYWSRRITDEHRLVYTVEQNEIVIIAA
RHHY

Nucleotide

• Length: 255 bp

>T211836 NZ_CP106786:c1014573-1014103 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8724.99 Da
• Isoelectric Point: 5.5609

>AT211836 WP_219903404.1 NZ_CP080383:2315045-2315290 [Cryobacterium sp. PAMC25264]
VAITASQARAQLFPLIEKVNEDHMPIEIVSKKGSAVLMSLADYEALEETAYLLRSPANAAHLLESIAQHRAGTASVRPLA
E

Nucleotide

• Length: 246 bp

>AT211836 NZ_CP106786:c1015013-1014570 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCAGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA