Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3218521..3219154 Replicon chromosome
Accession NZ_CP080378
Organism Massilia sp. PAMC28688

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KY495_RS14375 Protein ID WP_219880087.1
Coordinates 3218521..3218913 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KY495_RS14380 Protein ID WP_219880088.1
Coordinates 3218927..3219154 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY495_RS14355 (KY495_14355) 3214696..3215757 - 1062 WP_219880085.1 SRPBCC domain-containing protein -
KY495_RS14360 (KY495_14360) 3215754..3216638 - 885 WP_229518304.1 acyl-CoA desaturase -
KY495_RS14365 (KY495_14365) 3216645..3217925 - 1281 WP_219880086.1 molybdopterin molybdotransferase MoeA -
KY495_RS14370 (KY495_14370) 3217922..3218524 - 603 WP_229518305.1 molybdenum cofactor guanylyltransferase MobA -
KY495_RS14375 (KY495_14375) 3218521..3218913 - 393 WP_219880087.1 type II toxin-antitoxin system VapC family toxin Toxin
KY495_RS14380 (KY495_14380) 3218927..3219154 - 228 WP_219880088.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KY495_RS14385 (KY495_14385) 3219208..3220266 - 1059 WP_229518630.1 GTP 3',8-cyclase MoaA -
KY495_RS14390 (KY495_14390) 3220301..3221638 - 1338 WP_219880090.1 chromate efflux transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14348.49 Da        Isoelectric Point: 6.7588

>T211834 WP_219880087.1 NZ_CP080378:c3218913-3218521 [Massilia sp. PAMC28688]
MLDTNILIYLIKQKPAQVMRRFSTHALTDISVSSISVAELEFGVTKSGSTRNQEALHGWLQLLHRPAFDDHAAHTYGLLR
TALEANGTPIGPLDTLIAAHAMALDMTLVTNNVREFSRVPGLLIEDWTKA

Download         Length: 393 bp

>T211834 NZ_CP106786:c792226-791756 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8733.90 Da        Isoelectric Point: 7.0111

>AT211834 WP_219880088.1 NZ_CP080378:c3219154-3218927 [Massilia sp. PAMC28688]
MATAKVFMSGRSQAVRLPKEFRVGVTELAITRIGRSLVLTPKDPQWSDFFDMLQHFDDTAPVERNQPQEQQQRDW

Download         Length: 228 bp

>AT211834 NZ_CP106786:c792666-792223 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCAGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References