Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/StbC(antitoxin)
Location 2947798..2948436 Replicon chromosome
Accession NZ_CP080377
Organism Janthinobacterium sp. PAMC25594

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KY494_RS13235 Protein ID WP_219891238.1
Coordinates 2947798..2948220 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KY494_RS13240 Protein ID WP_219891239.1
Coordinates 2948227..2948436 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY494_RS13210 (KY494_13210) 2943926..2945122 + 1197 WP_219891236.1 type II secretion system F family protein -
KY494_RS13215 (KY494_13215) 2945227..2946096 + 870 WP_219135119.1 A24 family peptidase -
KY494_RS13220 (KY494_13220) 2946119..2946766 + 648 WP_219135118.1 dephospho-CoA kinase -
KY494_RS13225 (KY494_13225) 2946829..2947584 + 756 WP_219891237.1 cell division protein ZapD -
KY494_RS13230 (KY494_13230) 2947596..2947784 + 189 WP_101483945.1 DNA gyrase inhibitor YacG -
KY494_RS13235 (KY494_13235) 2947798..2948220 - 423 WP_219891238.1 hypothetical protein Toxin
KY494_RS13240 (KY494_13240) 2948227..2948436 - 210 WP_219891239.1 DNA-binding protein Antitoxin
KY494_RS13245 (KY494_13245) 2948552..2948974 - 423 WP_219891240.1 NUDIX domain-containing protein -
KY494_RS13250 (KY494_13250) 2948971..2949852 - 882 WP_219135112.1 ATP-binding protein -
KY494_RS13255 (KY494_13255) 2949849..2951087 - 1239 WP_219891241.1 bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ -
KY494_RS13260 (KY494_13260) 2951571..2952638 + 1068 WP_219891242.1 alpha/beta hydrolase -
KY494_RS29750 2952714..2952779 - 66 WP_258194929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15117.45 Da        Isoelectric Point: 5.6436

>T211833 WP_219891238.1 NZ_CP080377:c2948220-2947798 [Janthinobacterium sp. PAMC25594]
MPMPAYLVDTDVIVAARKGGAAPPGVADFFERVAPEMRYVPVQVIAQLRAGIQRSWRREAALEALALEGWLEAVLAEYAS
RLLEFDLDCALVCARLHARGHAHGVDGQIAAMGIAYGLTVVSGRLDSFAAQGLRLENPFN

Download         Length: 423 bp

>T211833 NZ_CP106786:356149-356496 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
ATTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7972.14 Da        Isoelectric Point: 7.3210

>AT211833 WP_219891239.1 NZ_CP080377:c2948436-2948227 [Janthinobacterium sp. PAMC25594]
MPLTLTFTDTDELLIAALHKRARAHGRSIEEEHRDILRNALRPLPKRPLDDILRSMPDVGLDADFQRRS

Download         Length: 210 bp

>AT211833 NZ_CP106786:356496-356795 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGATAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References