Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2156852..2157429 Replicon chromosome
Accession NZ_CP080377
Organism Janthinobacterium sp. PAMC25594

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag KY494_RS09605 Protein ID WP_219890778.1
Coordinates 2157103..2157429 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag KY494_RS09600 Protein ID WP_219890777.1
Coordinates 2156852..2157106 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY494_RS29690 2151908..2152048 + 141 Protein_1902 IS3 family transposase -
KY494_RS09570 (KY494_09570) 2152202..2152420 + 219 WP_219890772.1 LytTR family DNA-binding domain-containing protein -
KY494_RS09575 (KY494_09575) 2152525..2152854 + 330 WP_219890773.1 hypothetical protein -
KY494_RS09580 (KY494_09580) 2153131..2153844 - 714 WP_219890774.1 hypothetical protein -
KY494_RS09585 (KY494_09585) 2154888..2155091 + 204 Protein_1906 FGGY-family carbohydrate kinase -
KY494_RS09590 (KY494_09590) 2155257..2155535 + 279 WP_219890775.1 hypothetical protein -
KY494_RS09595 (KY494_09595) 2155696..2156691 + 996 WP_219890776.1 IS481 family transposase -
KY494_RS09600 (KY494_09600) 2156852..2157106 + 255 WP_219890777.1 antitoxin Antitoxin
KY494_RS09605 (KY494_09605) 2157103..2157429 + 327 WP_219890778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KY494_RS09610 (KY494_09610) 2157718..2158098 + 381 WP_219890779.1 response regulator -
KY494_RS09615 (KY494_09615) 2158298..2159515 + 1218 WP_219890780.1 HD-GYP domain-containing protein -
KY494_RS09620 (KY494_09620) 2159712..2162198 - 2487 WP_219890781.1 hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2115558..2193975 78417
- flank IS/Tn - - 2155696..2156691 995


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11645.65 Da        Isoelectric Point: 9.8348

>T211832 WP_219890778.1 NZ_CP080377:2157103-2157429 [Janthinobacterium sp. PAMC25594]
MKQGDIYIVSLDPIAGREKSSSLPVLVVSPAEFNAATKLPVILPITNASEFSSRLGFSVIVTGIKTTGIVRCDQPRVIDL
VARHARKIDTLPKSTLNEVLAKVATLFE

Download         Length: 327 bp

>T211832 NZ_CP106786:330178-330546 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9082.34 Da        Isoelectric Point: 4.9601

>AT211832 WP_219890777.1 NZ_CP080377:2156852-2157106 [Janthinobacterium sp. PAMC25594]
MHTTRLRKVGGSIMLAIPPAFLEQLDLQAGATVSVAVDHGCLVVDSKPRPRYTLTELLAASDYSQHQPADERDWIDAPAI
GGEL

Download         Length: 255 bp

>AT211832 NZ_CP106786:329960-330181 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References