Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2739655..2740229 Replicon chromosome
Accession NZ_CP080376
Organism Brevundimonas sp. PAMC22021

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KY493_RS13505 Protein ID WP_219896834.1
Coordinates 2739864..2740229 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KY493_RS13500 Protein ID WP_219896833.1
Coordinates 2739655..2739870 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY493_RS13480 (KY493_13480) 2734856..2735344 - 489 WP_219896829.1 Lrp/AsnC family transcriptional regulator -
KY493_RS13485 (KY493_13485) 2735489..2736724 + 1236 WP_219896830.1 thiamine pyrophosphate-dependent enzyme -
KY493_RS13490 (KY493_13490) 2736727..2737866 + 1140 WP_219896831.1 alpha-ketoacid dehydrogenase subunit beta -
KY493_RS13495 (KY493_13495) 2737868..2739592 + 1725 WP_219896832.1 2-oxo acid dehydrogenase subunit E2 -
KY493_RS13500 (KY493_13500) 2739655..2739870 + 216 WP_219896833.1 ribbon-helix-helix domain-containing protein Antitoxin
KY493_RS13505 (KY493_13505) 2739864..2740229 + 366 WP_219896834.1 type II toxin-antitoxin system VapC family toxin Toxin
KY493_RS13510 (KY493_13510) 2740240..2741646 + 1407 WP_219896835.1 dihydrolipoyl dehydrogenase -
KY493_RS13515 (KY493_13515) 2741874..2744729 + 2856 WP_219896836.1 pitrilysin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13515.63 Da        Isoelectric Point: 6.7274

>T211831 WP_219896834.1 NZ_CP080376:2739864-2740229 [Brevundimonas sp. PAMC22021]
MVAALFDSNILVDHMRGFPQAKAEVDRYEDRAISIVTWIEIMVGVPDHLTMPAREFLGEFSVVGLDRGVAERAVTIRKSH
RLKLPDAVIWAAAQTTGRLLVTRNTKDFPVDDPGVRSPYVL

Download         Length: 366 bp

>T211831 NZ_CP106785:c5235080-5234898 [Pseudomonas tohonis]
ATGCGCAGCCGTGAGGTGATAGAGAAGATCAAGGAGGATGGGTGGTATGAGGTGGATGTGAAAGGCAGTCACCATCAGTT
CAAACACCCGAGTAAACCGGGACGGGTCACGGTCCCACACCCCAGGAGCGATCTACCCATAGGGACGGTACGCAGCATTC
TGAAACAAGCCGGGCTCCTTTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7979.99 Da        Isoelectric Point: 4.7571

>AT211831 WP_219896833.1 NZ_CP080376:2739655-2739870 [Brevundimonas sp. PAMC22021]
VRILVDASEAQVAALDDLAKREKQPRAVVIRAAIDDYVARNTRKAALENSFGIWPDGPDGLEFQEKLRSEW

Download         Length: 216 bp

>AT211831 NZ_CP106785:c5234860-5234453 [Pseudomonas tohonis]
ATGAAATTTCCCATCGTTCTGCACAAGGATCCTGACTCTGACTACGGCGTTACCGTGCCGGACGTGCCGGGTTGTTTCTC
TGCGGGCGCTACCGTGGCGGAAGCCCTGGAGAACGTGAAGGAGGCGCTTGCCCTTCACTTCGAAGGCTTGGTGGCGGATG
GCGAGACGTTGCCTCAAGCGCAGCAAATTGATGTCTACATTGGTAATCCCGACTTTGCCGGTGGCGTGTGGGCCGTGGTC
GAGTTCGATGTGACACCGTATTTAGGCAAGGCCGTCCGCTTCAATGCCACCCTGCCAGAGAATCTTCTGCGGAGGATTGA
TGAGCGCGTGGGCAAAGACGCCCGCTACGCCTCGCGATCCGGCTTTCTGGCCACTGCCGCATTGCGCGAGCTTTCGGATG
CCAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References