Detailed information of TA system TA211830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2254765..2255418
• Replicon: chromosome
• Accession: NZ_CP080376
• Organism: Brevundimonas sp. PAMC22021

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KY493_RS11170
• Protein ID: WP_219896414.1
• Coordinates: 2254999..2255418 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KY493_RS11165
• Protein ID: WP_219896413.1
• Coordinates: 2254765..2254998 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KY493_RS11150 (KY493_11150)	2251860..2252156	-	297	WP_255568138.1	endonuclease domain-containing protein	-
KY493_RS11155 (KY493_11155)	2252226..2254091	-	1866	Protein_2191	DNA helicase RecQ	-
KY493_RS11160 (KY493_11160)	2254173..2254718	+	546	WP_219896412.1	5-formyltetrahydrofolate cyclo-ligase	-
KY493_RS11165 (KY493_11165)	2254765..2254998	+	234	WP_219896413.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KY493_RS11170 (KY493_11170)	2254999..2255418	+	420	WP_219896414.1	type II toxin-antitoxin system VapC family toxin	Toxin
KY493_RS11175 (KY493_11175)	2255415..2256239	+	825	WP_219896415.1	TIGR00282 family metallophosphoesterase	-
KY493_RS11180 (KY493_11180)	2256236..2257840	-	1605	WP_255567868.1	alkaline phosphatase D family protein	-
KY493_RS11185 (KY493_11185)	2258045..2259142	-	1098	WP_219896416.1	GTP-binding protein	-
KY493_RS11190 (KY493_11190)	2259185..2260051	-	867	WP_255567869.1	cation diffusion facilitator family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• SpoVT-AbrB domain (10-56)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15216.54 Da
• Isoelectric Point: 7.3859

>T211830 WP_219896414.1 NZ_CP080376:2254999-2255418 [Brevundimonas sp. PAMC22021]
VYLLDSDICVRLLRNRPPELAERLNAHASRLFTSAVVQHELMHGAMMSMRPDVQRAAVEALLSRMVVLDFDSAAADHAAD
IKASLQRRGTMIGGNDLLIAGHARSRSLIVVTGNLREFGRVEGLRCEDWPAGPAGPYLT

Nucleotide

• Length: 420 bp

>T211830 NZ_CP106785:c4775711-4774959 [Pseudomonas tohonis]
ATGGATATCTGGACGACCTGCCAGGGCCCGCAACACGTCGGGCCCCTGCGTGGCCGCCTGGTGCGCTTGGTGGAGAGCCA
GGAGCAGGTGGCGACCCTGCAGCTGGTGGACAACCTCGCCGAACAGGCGTTGCTGGAGGAACTCATCGAGACCAGCAAGC
CGCCGTTGCCCAGGAGCGCCGAGCCGCTGCACTACCTGCTCAAGACCCCGTTCCGCTACCCGCCGCTGCGCTGGGGGTCG
CGCTTCGGCACCGTCCACGAGCCGAGCCTGTTCTACGCCGCCTCGCGCCTGGAGACCGCCATGGCCGAGGGGGCGTTCTA
CCGCTTCGTCCTGTGGAGCGGCATGGCCGTGCCGCCCCCCAGCGGGCGCATCCTGTCCGAGCATTCCTCCTTCGAGGCGC
GTTTCCAGGTGGAGCGTGGCGTGCAGCTGCAATTGCCACCGTTCGATCGTCACGCTCAGGCACTGGCCGACCCGGTGGAC
TACCGCGCCAGCCAGGCGCTCGGCGCGGCCATGCGTGCCGCAGGCGTGGAGGCCTTCGAGTACCGCTCCGCGCGCTGCCC
GCTGCAGGGCACCAATATCGCCCTGTTCACCCCCGAGGCCTTCACCGAGCGGCGACCACGCAACCTCACGCCCTGGCTCT
GCGAGACCACCGCCGAGTACGTCGCCTTCAAGCATGCCCAGGCGCCGGATACGCCGCGCCTGTTCCGCATGACGCAATTC
CTGATCGACGGCCACCTGCCACAGCCGGCATGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8519.80 Da
• Isoelectric Point: 4.4299

>AT211830 WP_219896413.1 NZ_CP080376:2254765-2254998 [Brevundimonas sp. PAMC22021]
MNAPLKATVFKSNRSQAVRLPKAVAFPEDVKELRVIKEGKGLLLVPADAVWDDFLKEPGIDIRIADDPVDDEVVSFD

Nucleotide

• Length: 234 bp

>AT211830 NZ_CP106785:c4776118-4775747 [Pseudomonas tohonis]
ATGAGCGCCCTCAGCCGTCCCACTCTCGATCCCGATGCCGTCCTGGCCAAGGCCCTGCTCAATACCCGCGAGCAACTCGG
GCTGACCCAGCAGCAACTGGCCGACATCGTCGGTGTGCACCGCACCGCCATCACCCGCTGGGCGGACAGCGGCGGCATCC
GTCCGCAGAGCAAGACCGGCGAGCTCGCGCTGCTGCTGATCCGCGCCTACCGCGCATTGTTCGCCCTGTTCGGCGGCAAT
CTCGACGACATGCGCCACTTCCTGCGCACCGAGAACCGCCACCTGGGCGCCGTTCCCCTCGAACTGATGGGCCAGGTGCA
GGGTCTGGTGAGGGTGGTGGAGTACCTGGACGCCATACGCGGCAAGATCTGA