Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1911434..1912016 Replicon chromosome
Accession NZ_CP080376
Organism Brevundimonas sp. PAMC22021

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KY493_RS09405 Protein ID WP_219896098.1
Coordinates 1911828..1912016 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KY493_RS09400 Protein ID WP_219896097.1
Coordinates 1911434..1911823 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY493_RS09365 (KY493_09365) 1906709..1907410 + 702 WP_219896090.1 response regulator transcription factor -
KY493_RS09370 (KY493_09370) 1907653..1908441 + 789 WP_219896091.1 RNA methyltransferase -
KY493_RS09375 (KY493_09375) 1908438..1908758 + 321 WP_219896092.1 YnfA family protein -
KY493_RS09380 (KY493_09380) 1908778..1909887 + 1110 WP_219896093.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
KY493_RS09385 (KY493_09385) 1909932..1910159 + 228 WP_219896094.1 hypothetical protein -
KY493_RS09390 (KY493_09390) 1910156..1910566 + 411 WP_219896095.1 type II toxin-antitoxin system VapC family toxin -
KY493_RS09395 (KY493_09395) 1910569..1911402 + 834 WP_219896096.1 S-formylglutathione hydrolase -
KY493_RS09400 (KY493_09400) 1911434..1911823 - 390 WP_219896097.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KY493_RS09405 (KY493_09405) 1911828..1912016 - 189 WP_219896098.1 type II toxin-antitoxin system HicA family toxin Toxin
KY493_RS09410 (KY493_09410) 1912063..1912290 + 228 WP_219896099.1 hypothetical protein -
KY493_RS09415 (KY493_09415) 1912384..1912998 + 615 WP_219896100.1 superoxide dismutase -
KY493_RS09420 (KY493_09420) 1913064..1914083 + 1020 WP_255567848.1 MBL fold metallo-hydrolase -
KY493_RS09425 (KY493_09425) 1914295..1914516 - 222 WP_219896101.1 hypothetical protein -
KY493_RS09430 (KY493_09430) 1914771..1915388 + 618 WP_219896102.1 30S ribosomal protein S4 -
KY493_RS09435 (KY493_09435) 1915565..1915960 + 396 WP_219896103.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-123)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7107.17 Da        Isoelectric Point: 11.8099

>T211829 WP_219896098.1 NZ_CP080376:c1912016-1911828 [Brevundimonas sp. PAMC22021]
VNSRDIIRALEADGWFEVAHKGSHKQFKHPTRPGRVTLVHPRRDLPIGTLRSIEQQSGLKLR

Download         Length: 189 bp

>T211829 NZ_CP106785:c4763490-4762921 [Pseudomonas tohonis]
ATGTTCAATCCGCAACCGGTCATCCTGCAGCGCGGCGCCTTGCGCCTCGAGCCGCTGGGGGAGGCCGACGTCACCGAACT
CTCGGCACTGGCCGAGGCCAATCGCGATGAGCTGGTCTACATGAGCGGCCCGCTGCGCCCGGACTGGTACCGCCAGGGCC
TGGCCGAGCAGCGTGAAGGCCAGGCCGTGGTGTTCGCCATCCGCCTGGGCGACCGCCTGGTGGGTACCAGCCGCTTCGCC
GATTTCATGCCCGCGCTGCCGGCCGTGGAGATCGGCTGGACCTGGCTGGCCCGCAGCGAGCATGCCAGCGGCCTCAATGC
CTCGATCAAGTACCTGATGCTGCGCCATGCCTTCGAGGAGTGGCAGGTGGTGCGCGTGCAACTGAAGACCGCCGGCAGCA
ACCTGCGCTCGCAGAAGGCCATCGAGAAACTCGGTGCCCAGCGCGAAGGCGTCCTGCGCAACCATCGCCGCCTGGCGGAC
GGGCGCCTCGACGACAGCGTGCTCTACAGCATCACCGACCATGAGTGGCCGGCCGTGAAGCAGGCCCTGGAAGCCTCTTT
CGGCCAATGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13893.57 Da        Isoelectric Point: 4.4664

>AT211829 WP_219896097.1 NZ_CP080376:c1911823-1911434 [Brevundimonas sp. PAMC22021]
MAHYIALIHKDESSDYGVSFPDLPGLATAGASLDEARAFAEEALALHLEGLAEDGEPIPEPSSLDALMNEAENRRAVAIM
VRAETQARTVRVNITVPEDTLREIDRYAEAHGFTRSGFLAQAAKKAMAA

Download         Length: 390 bp

>AT211829 NZ_CP106785:c4762924-4762082 [Pseudomonas tohonis]
ATGAGCGCGGGTGGCGAGCGGACGCGCTTCTGGCAGGCCAGCGCGCTGGGCGGGGTCGAACTCCTGCACGCGCGCTACAT
CGAGCAGCGTTTCTCGCCCCATGTGCACGAGGGCTACGTCTTCACCGTCCTCGAATCCGGCGCCCAGCGCTTCCGCCACC
GCGGCAGCGACCACCTGGCTGCCGTCGGCAGCATGGTGCTGATTAACCCGGACGAGCTGCACACGGGCTCCAAGGCCCAC
GAGGAAGGATGGCGCTACCGCGGCTTCTACCCCGACCTGCACCGGGTGACCGAGGTGCTGGACGAACTGGAGATCGCCAC
CGGCGGCCTGCCCACCTTCGCCGACAGCGTGCTGCACGATCCCGAGGTGACCCGCCGCTTCCTCGACCTGCACCGCCTGC
TGGAGCGCAACGCCTCCGCTCTCGAGCAGCAGGTGGCCTGGCGCGAGGCGATCTTGCTGCTGTTCAGCCGCCACGCGCGC
ATTGGTGCGCCCCGGCCGGCAGGGCCGGAGCCCCATGCCGTGGCGCTGGCCCGCGAAATGCTGGCGGCGCGCCTGGCCTC
GCCGCCATCCCTTGAGGAGCTGGCCGCCCTGGTGGGGCTTTCGCCGTTCCATTTCGCCCGGGTGTTCCGCCGGGCCACCG
GGTTGCCGCCCCACGCCTGGTTGAAGCAGCGTCGCCTGGAGCAGGCTCGGGCGCTGCTGCGCGAAGGCTGCGCGCCGCTG
CCGGTGGCGATGCAGCTGGGCTTCGCCGACCAGAGCCACCTGACCCGCCAGTTCAAGCAGGCTTACGGCGTCGGTCCGGG
TGAGTACCGCAGCGCCTGCGCAAGATCGTTCAAGACCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References