Detailed information of TA system TA211828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 457980..458509
• Replicon: chromosome
• Accession: NZ_CP080376
• Organism: Brevundimonas sp. PAMC22021

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KY493_RS02100
• Protein ID: WP_219897355.1
• Coordinates: 458222..458509 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: KY493_RS02095
• Protein ID: WP_219897354.1
• Coordinates: 457980..458219 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KY493_RS02070 (KY493_02070)	453410..454207	+	798	WP_219897349.1	pyrroline-5-carboxylate reductase dimerization domain-containing protein	-
KY493_RS02075 (KY493_02075)	454215..454727	-	513	WP_219897350.1	hypothetical protein	-
KY493_RS02080 (KY493_02080)	454797..456143	-	1347	WP_219897351.1	ATP-binding protein	-
KY493_RS02085 (KY493_02085)	456145..456882	-	738	WP_219897352.1	response regulator transcription factor	-
KY493_RS02090 (KY493_02090)	456965..457843	+	879	WP_219897353.1	branched-chain amino acid aminotransferase	-
KY493_RS02095 (KY493_02095)	457980..458219	+	240	WP_219897354.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
KY493_RS02100 (KY493_02100)	458222..458509	+	288	WP_219897355.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KY493_RS02105 (KY493_02105)	458614..459888	+	1275	WP_219897356.1	nucleoside transporter C-terminal domain-containing protein	-
KY493_RS02110 (KY493_02110)	459918..460538	+	621	WP_219897357.1	glutathione S-transferase	-
KY493_RS02115 (KY493_02115)	460535..461047	+	513	WP_219897358.1	2'-5' RNA ligase family protein	-
KY493_RS02120 (KY493_02120)	461044..461478	-	435	WP_219897359.1	PaaI family thioesterase	-
KY493_RS02125 (KY493_02125)	461527..461835	+	309	WP_219897360.1	DUF3253 domain-containing protein	-
KY493_RS02130 (KY493_02130)	461819..462469	+	651	WP_219897361.1	uracil-DNA glycosylase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-90)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10705.21 Da
• Isoelectric Point: 6.7152

>T211828 WP_219897355.1 NZ_CP080376:458222-458509 [Brevundimonas sp. PAMC22021]
VKSLAFTPAAVADLDAIWDYTAEHWSADQADRYIDGLRDVCLELADGTRTGRVVEVRPGYLKQAVGSHMIYFRLGDGRVQ
VMRILHQSMDVARRL

Nucleotide

• Length: 288 bp

>T211828 NZ_CP106785:4420720-4421016 [Pseudomonas tohonis]
ATGACTGAAGACTTTTCCCGCTGGGACTCCGCCGACTACCTGCGTAGCGAGGAAGACATGGCCAACTACCTGGATGCCTG
CATCGAGGAAGCCGGCGACGATCCCGCCTTCATCGCCAAGGCCCTCGGCACCCTCGCCCGCGCCAAGGGCATGACCCAGG
TCGCCCGCGACACCGGCCTCTCGCGCGAGAGCCTGTACCGCGCGCTGTCCGGCGAGGGCAATCCCGAGTTCGGCACCATC
CTCAAGGTCCTCAGGGCACTCGGCCTGCAACTGCACGCCAGCCCCGCCCGCCACTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8577.52 Da
• Isoelectric Point: 7.2034

>AT211828 WP_219897354.1 NZ_CP080376:457980-458219 [Brevundimonas sp. PAMC22021]
MSRNTSVSLGQHFAGFIDGQVQSGRYGSASDVVRAGLRLLEEHEARIQALQAALLEGERSGEPQPFDFDAFKAGKRASR

Nucleotide

• Length: 240 bp

>AT211828 NZ_CP106785:4420419-4420727 [Pseudomonas tohonis]
ATGATCAAGGTCCTCCAGAGCAGGGCGTTCGCCACTTGGCTGAACCACCTGAGCGACGGCAAGGCCAGGGCACGGATACT
GGCTCGCATCGACCGCATGGCCGACGGCCACCTGGGGGACGTCGCACCGATAGGCGAAGGCCTCAGCGAAGCCCGGCTCC
ACTTCGGCCCCGGCTACCGGCTCTACTTTCTCCAGCGCGGCCGGTTCCTGATCGTCCTCCTCTGCGGTGGCGACAAGGGC
AGCCAGGGGCGAGATATCGGACACGCCAGGCGCATCGCCGCAGCCTGGAAGGAGCAACACCATGACTGA