Detailed information of TA system TA211814

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2806278..2807122
• Replicon: chromosome
• Accession: NZ_CP080370
• Organism: Escherichia coli strain PK5086

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: K0H55_RS13620
• Protein ID: WP_000854686.1
• Coordinates: 2806278..2806661 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: K0H55_RS13625
• Protein ID: WP_001285602.1
• Coordinates: 2806742..2807122 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0H55_RS13580 (2801281)	2801281..2801772	-	492	WP_001297187.1	DUF1097 domain-containing protein	-
K0H55_RS13585 (2801874)	2801874..2802428	-	555	WP_001001902.1	molecular chaperone YcdY	-
K0H55_RS13590 (2802452)	2802452..2803189	-	738	WP_000283664.1	zinc-binding phosphatase	-
K0H55_RS13595 (2803244)	2803244..2804182	-	939	WP_000351311.1	glyoxylate/hydroxypyruvate reductase GhrA	-
K0H55_RS13605 (2804653)	2804653..2805494	-	842	Protein_2673	DUF4942 domain-containing protein	-
K0H55_RS13610 (2805579)	2805579..2805776	-	198	WP_000839253.1	DUF957 domain-containing protein	-
K0H55_RS13615 (2805793)	2805793..2806281	-	489	WP_032180032.1	DUF5983 family protein	-
K0H55_RS13620 (2806278)	2806278..2806661	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
K0H55_RS13625 (2806742)	2806742..2807122	-	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
K0H55_RS13630 (2807133)	2807133..2807816	-	684	WP_000086768.1	hypothetical protein	-
K0H55_RS13635 (2807835)	2807835..2808056	-	222	WP_000692298.1	DUF987 domain-containing protein	-
K0H55_RS13640 (2808119)	2808119..2808595	-	477	WP_001186726.1	RadC family protein	-
K0H55_RS13645 (2808611)	2808611..2809096	-	486	WP_000214307.1	antirestriction protein	-
K0H55_RS13650 (2809188)	2809188..2810009	-	822	WP_001761104.1	DUF932 domain-containing protein	-
K0H55_RS13655 (2810110)	2810110..2810318	-	209	Protein_2683	DUF905 family protein	-
K0H55_RS13660 (2810419)	2810419..2810874	-	456	WP_000581506.1	IrmA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T211814 WP_000854686.1 NZ_CP080370:c2806661-2806278 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T211814 NZ_CP106783:2545-2823 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT211814 WP_001285602.1 NZ_CP080370:c2807122-2806742 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT211814 NZ_CP106783:2360-2545 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA