Detailed information of TA system TA211795

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 49342..50143
• Replicon: chromosome
• Accession: NZ_CP080370
• Organism: Escherichia coli strain PK5086

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A0E0XS49
• Locus tag: K0H55_RS00260
• Protein ID: WP_001094437.1
• Coordinates: 49342..49719 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A0E0XTQ1
• Locus tag: K0H55_RS00265
• Protein ID: WP_001390338.1
• Coordinates: 49766..50143 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0H55_RS00230 (44699)	44699..45622	-	924	WP_000535960.1	carboxylate/amino acid/amine transporter	-
K0H55_RS00235 (45733)	45733..46917	-	1185	WP_001172877.1	sugar efflux transporter	-
K0H55_RS00240 (47347)	47347..47475	-	129	Protein_46	RhuM family protein	-
K0H55_RS00245 (47710)	47710..48555	-	846	WP_001274561.1	DUF4942 domain-containing protein	-
K0H55_RS00250 (48640)	48640..48837	-	198	WP_000772032.1	DUF957 domain-containing protein	-
K0H55_RS00255 (48857)	48857..49345	-	489	WP_000761716.1	DUF5983 family protein	-
K0H55_RS00260 (49342)	49342..49719	-	378	WP_001094437.1	TA system toxin CbtA family protein	Toxin
K0H55_RS00265 (49766)	49766..50143	-	378	WP_001390338.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
K0H55_RS00270 (50306)	50306..50527	-	222	WP_000692345.1	DUF987 domain-containing protein	-
K0H55_RS00275 (50590)	50590..51066	-	477	WP_001186747.1	RadC family protein	-
K0H55_RS00280 (51082)	51082..51252	-	171	Protein_54	antirestriction protein	-
K0H55_RS00285 (51254)	51254..52018	-	765	Protein_55	ESPR-type extended signal peptide-containing protein	-
K0H55_RS00290 (52390)	52390..53154	-	765	WP_162869019.1	GTPase family protein	-
K0H55_RS00295 (53544)	53544..53755	+	212	Protein_57	hemolysin expression modulator Hha	-
K0H55_RS24435 (54098)	54098..54295	-	198	WP_001545803.1	hypothetical protein	-
K0H55_RS00300 (54499)	54499..55068	+	570	WP_000148641.1	inovirus Gp2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13986.90 Da
• Isoelectric Point: 7.3223

>T211795 WP_001094437.1 NZ_CP080370:c49719-49342 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T211795 NZ_CP106769:c1651713-1651531 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13745.44 Da
• Isoelectric Point: 5.0463

>AT211795 WP_001390338.1 NZ_CP080370:c50143-49766 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Nucleotide

• Length: 378 bp

>AT211795 NZ_CP106769:c1651429-1651028 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: A0A0E0XS49

Antitoxin

• AlphaFold DB: A0A0E0XTQ1