Detailed information of TA system TA211793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 5833853..5834493
• Replicon: chromosome
• Accession: NZ_CP080369
• Organism: Pseudomonas aeruginosa SG17M

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K0E51_RS27195
• Protein ID: WP_003105740.1
• Coordinates: 5833853..5834263 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q6X2S2
• Locus tag: K0E51_RS27200
• Protein ID: WP_003158175.1
• Coordinates: 5834263..5834493 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0E51_RS27155 (K0E51_27155)	5829722..5829892	+	171	WP_003159716.1	hypothetical protein	-
K0E51_RS27160 (K0E51_27160)	5830048..5830776	+	729	WP_003105754.1	TIGR03761 family integrating conjugative element protein	-
K0E51_RS27165 (K0E51_27165)	5830782..5831330	+	549	WP_003105753.1	DUF3158 family protein	-
K0E51_RS27170 (K0E51_27170)	5831377..5832216	+	840	WP_003105750.1	Rha family transcriptional regulator	-
K0E51_RS27175 (K0E51_27175)	5832246..5832734	+	489	WP_003105748.1	single-stranded DNA-binding protein	-
K0E51_RS27180 (K0E51_27180)	5832890..5833087	+	198	WP_003109353.1	CrpP family ICE-associated protein	-
K0E51_RS27185 (K0E51_27185)	5833153..5833371	-	219	WP_003105747.1	hypothetical protein	-
K0E51_RS27190 (K0E51_27190)	5833571..5833831	-	261	WP_003105742.1	hypothetical protein	-
K0E51_RS27195 (K0E51_27195)	5833853..5834263	-	411	WP_003105740.1	tRNA(fMet)-specific endonuclease VapC	Toxin
K0E51_RS27200 (K0E51_27200)	5834263..5834493	-	231	WP_003158175.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
K0E51_RS27205 (K0E51_27205)	5834749..5836668	+	1920	WP_004352838.1	type I DNA topoisomerase	-
K0E51_RS27210 (K0E51_27210)	5836976..5837185	+	210	WP_003105733.1	cold-shock protein	-
K0E51_RS27215 (K0E51_27215)	5837406..5839295	+	1890	WP_003105732.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	5814282..5917861	103579

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

• SpoVT-AbrB domain (7-35)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15450.81 Da
• Isoelectric Point: 7.3233

>T211793 WP_003105740.1 NZ_CP080369:c5834263-5833853 [Pseudomonas aeruginosa SG17M]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVVPIV

Nucleotide

• Length: 411 bp

>T211793 NZ_CP106768:1785-2063 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8480.41 Da
• Isoelectric Point: 4.2821

>AT211793 WP_003158175.1 NZ_CP080369:c5834493-5834263 [Pseudomonas aeruginosa SG17M]
MEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVVVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Nucleotide

• Length: 231 bp

>AT211793 NZ_CP106768:1600-1785 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Structures

Antitoxin

• AlphaFold DB: Q6X2S2