Detailed information of TA system TA211792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 5115544..5116802
• Replicon: chromosome
• Accession: NZ_CP080369
• Organism: Pseudomonas aeruginosa SG17M

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: K0E51_RS23750
• Protein ID: WP_003112528.1
• Coordinates: 5115544..5116299 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: K0E51_RS23755
• Protein ID: WP_003086329.1
• Coordinates: 5116434..5116802 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0E51_RS23740 (K0E51_23740)	5110717..5113260	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
K0E51_RS23745 (K0E51_23745)	5113415..5114776	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
K0E51_RS23750 (K0E51_23750)	5115544..5116299	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
K0E51_RS23755 (K0E51_23755)	5116434..5116802	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
K0E51_RS23760 (K0E51_23760)	5116875..5118161	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
K0E51_RS23765 (K0E51_23765)	5118217..5119710	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
K0E51_RS23770 (K0E51_23770)	5119885..5120361	+	477	WP_003112531.1	hypothetical protein	-
K0E51_RS23775 (K0E51_23775)	5120364..5120639	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T211792 WP_003112528.1 NZ_CP080369:c5116299-5115544 [Pseudomonas aeruginosa SG17M]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T211792 NZ_CP106767:c1522761-1522579 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT211792 WP_003086329.1 NZ_CP080369:c5116802-5116434 [Pseudomonas aeruginosa SG17M]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT211792 NZ_CP106767:c1522477-1522076 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7