Detailed information of TA system TA211791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 4158790..4160011
• Replicon: chromosome
• Accession: NZ_CP080369
• Organism: Pseudomonas aeruginosa SG17M

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: K0E51_RS19220
• Protein ID: WP_003102740.1
• Coordinates: 4159433..4160011 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: K0E51_RS19215
• Protein ID: WP_003088112.1
• Coordinates: 4158790..4159344 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0E51_RS19190 (K0E51_19180)	4154358..4154909	+	552	WP_016253541.1	helix-turn-helix domain-containing protein	-
K0E51_RS19195 (K0E51_19185)	4154906..4155304	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
K0E51_RS19200 (K0E51_19190)	4155317..4155640	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
K0E51_RS19205 (K0E51_19195)	4155971..4156432	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
K0E51_RS19210 (K0E51_19200)	4156437..4158632	+	2196	WP_023087567.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
K0E51_RS19215 (K0E51_19205)	4158790..4159344	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
K0E51_RS19220 (K0E51_19210)	4159433..4160011	+	579	WP_003102740.1	HD domain-containing protein	Toxin
K0E51_RS19225 (K0E51_19215)	4160120..4161307	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
K0E51_RS19230 (K0E51_19220)	4161297..4163468	-	2172	WP_003088105.1	type I secretion system permease/ATPase	-
K0E51_RS19235 (K0E51_19225)	4163458..4164735	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T211791 WP_003102740.1 NZ_CP080369:4159433-4160011 [Pseudomonas aeruginosa SG17M]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T211791 NZ_CP106767:652386-652805 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT211791 WP_003088112.1 NZ_CP080369:4158790-4159344 [Pseudomonas aeruginosa SG17M]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT211791 NZ_CP106767:652150-652386 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07