Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3100908..3101950 | Replicon | chromosome |
| Accession | NZ_CP080369 | ||
| Organism | Pseudomonas aeruginosa SG17M | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | K0E51_RS14610 | Protein ID | WP_003050248.1 |
| Coordinates | 3101375..3101950 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | K0E51_RS14605 | Protein ID | WP_003050245.1 |
| Coordinates | 3100908..3101378 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K0E51_RS14570 (K0E51_14550) | 3096299..3097717 | - | 1419 | WP_023087297.1 | TIGR03752 family integrating conjugative element protein | - |
| K0E51_RS14575 (K0E51_14555) | 3097707..3098618 | - | 912 | WP_023087298.1 | TIGR03749 family integrating conjugative element protein | - |
| K0E51_RS14580 (K0E51_14560) | 3098615..3099307 | - | 693 | WP_023087299.1 | TIGR03746 family integrating conjugative element protein | - |
| K0E51_RS14585 (K0E51_14565) | 3099304..3099702 | - | 399 | WP_003105639.1 | TIGR03750 family conjugal transfer protein | - |
| K0E51_RS14590 (K0E51_14570) | 3099715..3100074 | - | 360 | WP_021195311.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| K0E51_RS14595 (K0E51_14575) | 3100091..3100324 | - | 234 | WP_003050225.1 | TIGR03758 family integrating conjugative element protein | - |
| K0E51_RS14600 (K0E51_14580) | 3100321..3100704 | - | 384 | WP_023087300.1 | RAQPRD family integrative conjugative element protein | - |
| K0E51_RS14605 (K0E51_14585) | 3100908..3101378 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| K0E51_RS14610 (K0E51_14590) | 3101375..3101950 | + | 576 | WP_003050248.1 | PIN domain-containing protein | Toxin |
| K0E51_RS14615 (K0E51_14595) | 3101968..3102882 | + | 915 | WP_023087301.1 | AAA family ATPase | - |
| K0E51_RS14620 (K0E51_14600) | 3102879..3103349 | + | 471 | WP_023087302.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
| K0E51_RS14625 (K0E51_14605) | 3103346..3103846 | + | 501 | WP_003050262.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| K0E51_RS14630 (K0E51_14610) | 3103846..3104748 | + | 903 | WP_023087303.1 | CBASS oligonucleotide cyclase | - |
| K0E51_RS14635 (K0E51_14615) | 3104785..3105510 | + | 726 | WP_023087304.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 3032231..3147438 | 115207 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21630.76 Da Isoelectric Point: 5.6130
>T211790 WP_003050248.1 NZ_CP080369:3101375-3101950 [Pseudomonas aeruginosa SG17M]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T211790 NZ_CP106766:1284-1562 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT211790 WP_003050245.1 NZ_CP080369:3100908-3101378 [Pseudomonas aeruginosa SG17M]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT211790 NZ_CP106766:1099-1284 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|