211787

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 366357..366862 Replicon chromosome
Accession NZ_CP080369
Organism Pseudomonas aeruginosa SG17M

Toxin (Protein)


Gene name parE Uniprot ID A0A7M2ZNP4
Locus tag K0E51_RS01675 Protein ID WP_009875660.1
Coordinates 366357..366638 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag K0E51_RS01680 Protein ID WP_003137009.1
Coordinates 366635..366862 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0E51_RS01650 (K0E51_01650) 361608..362957 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
K0E51_RS01655 (K0E51_01655) 363006..363692 + 687 WP_004351997.1 FadR/GntR family transcriptional regulator -
K0E51_RS01660 (K0E51_01660) 363793..364527 + 735 WP_003117208.1 GntR family transcriptional regulator -
K0E51_RS01665 (K0E51_01665) 364707..365117 + 411 WP_003101225.1 aegerolysin family protein -
K0E51_RS01670 (K0E51_01670) 365149..366057 - 909 WP_003083769.1 LysR family transcriptional regulator -
K0E51_RS01675 (K0E51_01675) 366357..366638 - 282 WP_009875660.1 type II toxin-antitoxin system toxin ParE Toxin
K0E51_RS01680 (K0E51_01680) 366635..366862 - 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
K0E51_RS01685 (K0E51_01685) 367038..367658 - 621 WP_023086863.1 hypothetical protein -
K0E51_RS01690 (K0E51_01690) 367759..368259 + 501 WP_003101228.1 LEA type 2 family protein -
K0E51_RS01695 (K0E51_01695) 368332..368673 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
K0E51_RS01700 (K0E51_01700) 368755..370182 - 1428 WP_003083784.1 GABA permease -
K0E51_RS01705 (K0E51_01705) 370351..371844 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10461.25 Da        Isoelectric Point: 10.4670

>T211787 WP_009875660.1 NZ_CP080369:c366638-366357 [Pseudomonas aeruginosa SG17M]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLKRWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T211787 NZ_CP106762:c29047-28898 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT211787 WP_003137009.1 NZ_CP080369:c366862-366635 [Pseudomonas aeruginosa SG17M]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp

>AT211787 NZ_CP106762:29092-29151 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7M2ZNP4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References