Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 167967..168610 Replicon plasmid pFII-191773
Accession NZ_CP080363
Organism Klebsiella pneumoniae strain K191773

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag K0P53_RS27105 Protein ID WP_014386165.1
Coordinates 168194..168610 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag K0P53_RS27100 Protein ID WP_032408893.1
Coordinates 167967..168197 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P53_RS27075 (K0P53_27075) 163040..164023 - 984 WP_001471744.1 NAD(P)H-quinone oxidoreductase -
K0P53_RS27080 (K0P53_27080) 164042..165190 - 1149 WP_014386168.1 ABC transporter ATP-binding protein -
K0P53_RS27085 (K0P53_27085) 165361..166518 - 1158 WP_032408895.1 acetylornithine deacetylase -
K0P53_RS27090 (K0P53_27090) 166534..167208 - 675 WP_014386166.1 DUF1028 domain-containing protein -
K0P53_RS27095 (K0P53_27095) 167213..167647 - 435 WP_000103648.1 RidA family protein -
K0P53_RS27100 (K0P53_27100) 167967..168197 + 231 WP_032408893.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K0P53_RS27105 (K0P53_27105) 168194..168610 + 417 WP_014386165.1 PIN domain-containing protein Toxin
K0P53_RS27110 (K0P53_27110) 168933..169901 + 969 WP_074422984.1 IS5-like element IS903B family transposase -
K0P53_RS27115 (K0P53_27115) 170081..170455 - 375 WP_032408891.1 hypothetical protein -
K0P53_RS27120 (K0P53_27120) 170511..170837 - 327 WP_004152639.1 hypothetical protein -
K0P53_RS27125 (K0P53_27125) 170834..171562 - 729 WP_014386162.1 plasmid SOS inhibition protein A -
K0P53_RS27130 (K0P53_27130) 171559..171990 - 432 WP_014386161.1 conjugation system SOS inhibitor PsiB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..190150 190150
- flank IS/Tn - - 168933..169901 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15127.44 Da        Isoelectric Point: 7.8841

>T211782 WP_014386165.1 NZ_CP080363:168194-168610 [Klebsiella pneumoniae]
MTKTYMLDTNICSYIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGAIGKRASPRHVQLVDAFCARLDAILAWDRA
AVDATTEVKATLAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVAGLTFEDWVQ

Download         Length: 417 bp

>T211782 NZ_CP106760:c5365141-5364758 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8854.89 Da        Isoelectric Point: 4.5112

>AT211782 WP_032408893.1 NZ_CP080363:167967-168197 [Klebsiella pneumoniae]
MRTVSVFRNGNNRAIRLPRDLDFDGVNELEIIREGDTLILRPVKPSWSSFRQEEKADADFMAERENVVSDEGRFEL

Download         Length: 231 bp

>AT211782 NZ_CP106760:c5365383-5365141 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References