Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 142747..143510 Replicon plasmid pFII-191773
Accession NZ_CP080363
Organism Klebsiella pneumoniae strain K191773

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag K0P53_RS26970 Protein ID WP_148053329.1
Coordinates 143001..143510 (+) Length 170 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag K0P53_RS26965 Protein ID WP_014386183.1
Coordinates 142747..143013 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P53_RS26915 (K0P53_26915) 138299..138712 - 414 WP_013023817.1 helix-turn-helix domain-containing protein -
K0P53_RS26920 (K0P53_26920) 138713..138991 - 279 WP_004152721.1 helix-turn-helix transcriptional regulator -
K0P53_RS26925 (K0P53_26925) 138981..139301 - 321 WP_014386190.1 type II toxin-antitoxin system RelE/ParE family toxin -
K0P53_RS26930 (K0P53_26930) 139382..139606 - 225 WP_014386189.1 hypothetical protein -
K0P53_RS26935 (K0P53_26935) 139617..139829 - 213 WP_014386188.1 hypothetical protein -
K0P53_RS26940 (K0P53_26940) 139891..140217 - 327 WP_014386187.1 hypothetical protein -
K0P53_RS26945 (K0P53_26945) 140854..141204 - 351 WP_014386186.1 hypothetical protein -
K0P53_RS26950 (K0P53_26950) 141201..141473 - 273 WP_032408902.1 hypothetical protein -
K0P53_RS26955 (K0P53_26955) 141663..142148 + 486 WP_014386185.1 hypothetical protein -
K0P53_RS26960 (K0P53_26960) 142392..142550 - 159 WP_014386184.1 type I toxin-antitoxin system Hok family toxin -
K0P53_RS26965 (K0P53_26965) 142747..143013 + 267 WP_014386183.1 DUF1778 domain-containing protein Antitoxin
K0P53_RS26970 (K0P53_26970) 143001..143510 + 510 WP_148053329.1 GNAT family N-acetyltransferase Toxin
K0P53_RS26975 (K0P53_26975) 143544..144764 + 1221 WP_000343760.1 ISL3-like element ISKox3 family transposase -
K0P53_RS26980 (K0P53_26980) 145257..145508 - 252 WP_032408900.1 aldo/keto reductase -
K0P53_RS26985 (K0P53_26985) 145705..147297 - 1593 Protein_160 IS66 family transposase -
K0P53_RS26990 (K0P53_26990) 147328..147678 - 351 WP_014386180.1 IS66 family insertion sequence element accessory protein TnpB -
K0P53_RS26995 (K0P53_26995) 147675..148115 - 441 WP_014386179.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..190150 190150


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(89-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18421.40 Da        Isoelectric Point: 9.2603

>T211781 WP_148053329.1 NZ_CP080363:143001-143510 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLG
LPLLWWLKA

Download         Length: 510 bp

>T211781 NZ_CP106760:c5040424-5039507 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.66 Da        Isoelectric Point: 5.1169

>AT211781 WP_014386183.1 NZ_CP080363:142747-143013 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK

Download         Length: 267 bp

>AT211781 NZ_CP106760:c5041188-5040430 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References