Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4749107..4749623 Replicon chromosome
Accession NZ_CP080362
Organism Klebsiella pneumoniae strain K191773

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K0P53_RS23565 Protein ID WP_002886902.1
Coordinates 4749107..4749391 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K0P53_RS23570 Protein ID WP_002886901.1
Coordinates 4749381..4749623 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P53_RS23540 (4744523) 4744523..4744786 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
K0P53_RS23545 (4744916) 4744916..4745089 + 174 WP_032410138.1 hypothetical protein -
K0P53_RS23550 (4745092) 4745092..4745835 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
K0P53_RS23555 (4746192) 4746192..4748330 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K0P53_RS23560 (4748639) 4748639..4749103 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K0P53_RS23565 (4749107) 4749107..4749391 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K0P53_RS23570 (4749381) 4749381..4749623 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K0P53_RS23575 (4749701) 4749701..4751611 - 1911 WP_009486549.1 PRD domain-containing protein -
K0P53_RS23580 (4751634) 4751634..4752788 - 1155 WP_023302389.1 lactonase family protein -
K0P53_RS23585 (4752855) 4752855..4753595 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T211777 WP_002886902.1 NZ_CP080362:c4749391-4749107 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T211777 NZ_CP106760:c3341015-3340839 [Klebsiella pneumoniae]
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AACTCGGTATCAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT211777 WP_002886901.1 NZ_CP080362:c4749623-4749381 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT211777 NZ_CP106760:c3340791-3340384 [Klebsiella pneumoniae]
ATGCGATACCCGGTAATTTTTGAGCATGACGAAACCGGCTGGGCGGTATTCTTTCCGGATATCCCAGAGGCAATGACGGG
AGGAGAGACCAGGGAGGAAGCGTTAGAAATGGCGCAAGATGCCCTGGTGACGGCGTTTGATTTTTACTTTGACGACCGCC
GGGAGATTCCCGCTCCATCAGCAGAAGGTGATGCGTTTGTTGAGGTTCCGGCCAGCGTGGCAGCTAAAGTATTGCTGTTA
AACCGTCTGGTCAGCACCAACACCAGCAATGCTGATCTCGCCCGCTTGATTAACACGCGCCCACAGGAAGTGCAGCGCAT
CGTGTCTCTTGGTCACAGTACCAAAATCGATACGATCCAAAAAGCGCTATCAGCGTTGGGGCAAAAGATGGAAATTGTCG
TCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References