Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4044887..4045506 Replicon chromosome
Accession NZ_CP080362
Organism Klebsiella pneumoniae strain K191773

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K0P53_RS20210 Protein ID WP_002892050.1
Coordinates 4045288..4045506 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K0P53_RS20205 Protein ID WP_002892066.1
Coordinates 4044887..4045261 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P53_RS20195 (4040039) 4040039..4041232 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K0P53_RS20200 (4041255) 4041255..4044401 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K0P53_RS20205 (4044887) 4044887..4045261 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K0P53_RS20210 (4045288) 4045288..4045506 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K0P53_RS20215 (4045669) 4045669..4046235 + 567 WP_002892030.1 maltose O-acetyltransferase -
K0P53_RS20220 (4046207) 4046207..4046347 - 141 WP_004147370.1 hypothetical protein -
K0P53_RS20225 (4046368) 4046368..4046838 + 471 WP_040182126.1 YlaC family protein -
K0P53_RS20230 (4046813) 4046813..4048264 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K0P53_RS20235 (4048365) 4048365..4049063 + 699 WP_002892021.1 GNAT family protein -
K0P53_RS20240 (4049060) 4049060..4049200 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K0P53_RS20245 (4049200) 4049200..4049463 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T211775 WP_002892050.1 NZ_CP080362:4045288-4045506 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T211775 NZ_CP106760:2014283-2014385 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT211775 WP_002892066.1 NZ_CP080362:4044887-4045261 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT211775 NZ_CP106760:c2014392-2014247 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References