211761

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2300..2774 Replicon plasmid unnamed1
Accession NZ_CP080354
Organism Klebsiella pneumoniae strain K191663

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag K0P45_RS26450 Protein ID WP_004197762.1
Coordinates 2508..2774 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag K0P45_RS26445 Protein ID WP_000879771.1
Coordinates 2300..2524 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P45_RS26425 (K0P45_26410) 1..227 + 227 WP_200493705.1 MobC family plasmid mobilization relaxosome protein -
K0P45_RS29000 436..870 + 435 Protein_1 relaxase/mobilization nuclease domain-containing protein -
K0P45_RS26435 (K0P45_26420) 905..1414 + 510 WP_032433972.1 MbeB family mobilization protein -
K0P45_RS26440 (K0P45_26425) 1421..1633 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
K0P45_RS29070 2009..2137 - 129 WP_000523570.1 hypothetical protein -
K0P45_RS26445 (K0P45_26430) 2300..2524 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
K0P45_RS26450 (K0P45_26435) 2508..2774 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K0P45_RS26455 (K0P45_26440) 2844..3194 - 351 WP_004197756.1 hypothetical protein -
K0P45_RS26460 (K0P45_26445) 3260..3805 - 546 WP_023317533.1 hypothetical protein -
K0P45_RS26465 (K0P45_26450) 3831..4157 - 327 WP_050516389.1 hypothetical protein -
K0P45_RS26470 (K0P45_26455) 5313..5489 + 177 WP_004197757.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T211761 WP_004197762.1 NZ_CP080354:2508-2774 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

>T211761 NZ_CP106757:c261159-261016 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCGACTTTAATCTTCGGAATCCTAAAGGTTGTTAAAGAAGACAAGAAAAAATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT211761 WP_000879771.1 NZ_CP080354:2300-2524 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp

>AT211761 NZ_CP106757:261270-261410 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTTTT
AGTTACAAAAAATAACCGTACTCAGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References