Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4805476..4805992 Replicon chromosome
Accession NZ_CP080353
Organism Klebsiella pneumoniae strain K191663

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K0P45_RS23795 Protein ID WP_002886902.1
Coordinates 4805476..4805760 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K0P45_RS23800 Protein ID WP_002886901.1
Coordinates 4805750..4805992 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P45_RS23770 (4800892) 4800892..4801200 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
K0P45_RS23775 (4801285) 4801285..4801458 + 174 WP_032410138.1 hypothetical protein -
K0P45_RS23780 (4801461) 4801461..4802204 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
K0P45_RS23785 (4802561) 4802561..4804699 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K0P45_RS23790 (4805008) 4805008..4805472 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K0P45_RS23795 (4805476) 4805476..4805760 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K0P45_RS23800 (4805750) 4805750..4805992 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K0P45_RS23805 (4806070) 4806070..4807980 - 1911 WP_009486549.1 PRD domain-containing protein -
K0P45_RS23810 (4808003) 4808003..4809157 - 1155 WP_023302389.1 lactonase family protein -
K0P45_RS23815 (4809224) 4809224..4809964 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T211758 WP_002886902.1 NZ_CP080353:c4805760-4805476 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T211758 NZ_CP106756:c4662679-4662572 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT211758 WP_002886901.1 NZ_CP080353:c4805992-4805750 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT211758 NZ_CP106756:4662737-4662793 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References