Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4720199..4721009 Replicon chromosome
Accession NZ_CP080353
Organism Klebsiella pneumoniae strain K191663

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag K0P45_RS23415 Protein ID WP_014908042.1
Coordinates 4720199..4720732 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag K0P45_RS23420 Protein ID WP_023343051.1
Coordinates 4720743..4721009 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P45_RS23410 (4719030) 4719030..4720151 + 1122 WP_012737335.1 cupin domain-containing protein -
K0P45_RS23415 (4720199) 4720199..4720732 - 534 WP_014908042.1 type II toxin-antitoxin system toxin KacT Toxin
K0P45_RS23420 (4720743) 4720743..4721009 - 267 WP_023343051.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
K0P45_RS23425 (4721112) 4721112..4722545 - 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
K0P45_RS23430 (4722535) 4722535..4723218 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
K0P45_RS23435 (4723391) 4723391..4724776 + 1386 WP_040182471.1 efflux transporter outer membrane subunit -
K0P45_RS23440 (4724794) 4724794..4725138 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T211757 WP_014908042.1 NZ_CP080353:c4720732-4720199 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T211757 NZ_CP106756:c4662196-4662089 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT211757 WP_023343051.1 NZ_CP080353:c4721009-4720743 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT211757 NZ_CP106756:4662253-4662310 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure

References