Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4102579..4103198 Replicon chromosome
Accession NZ_CP080353
Organism Klebsiella pneumoniae strain K191663

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K0P45_RS20445 Protein ID WP_002892050.1
Coordinates 4102980..4103198 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K0P45_RS20440 Protein ID WP_002892066.1
Coordinates 4102579..4102953 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P45_RS20430 (4097731) 4097731..4098924 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K0P45_RS20435 (4098947) 4098947..4102093 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K0P45_RS20440 (4102579) 4102579..4102953 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K0P45_RS20445 (4102980) 4102980..4103198 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K0P45_RS20450 (4103361) 4103361..4103927 + 567 WP_002892030.1 maltose O-acetyltransferase -
K0P45_RS20455 (4103899) 4103899..4104039 - 141 WP_004147370.1 hypothetical protein -
K0P45_RS20460 (4104060) 4104060..4104530 + 471 WP_040182126.1 YlaC family protein -
K0P45_RS20465 (4104505) 4104505..4105956 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K0P45_RS20470 (4106057) 4106057..4106755 + 699 WP_002892021.1 GNAT family protein -
K0P45_RS20475 (4106752) 4106752..4106892 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K0P45_RS20480 (4106892) 4106892..4107155 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T211756 WP_002892050.1 NZ_CP080353:4102980-4103198 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T211756 NZ_CP106756:c4661713-4661606 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT211756 WP_002892066.1 NZ_CP080353:4102579-4102953 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT211756 NZ_CP106756:4661761-4661827 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References