Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 786498..787155 Replicon chromosome
Accession NZ_CP080353
Organism Klebsiella pneumoniae strain K191663

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K0P45_RS03925 Protein ID WP_002916310.1
Coordinates 786745..787155 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K0P45_RS03920 Protein ID WP_002916312.1
Coordinates 786498..786764 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P45_RS03895 (781654) 781654..783087 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K0P45_RS03900 (783206) 783206..783934 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K0P45_RS03905 (783984) 783984..784295 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K0P45_RS03910 (784459) 784459..785118 + 660 WP_002916317.1 hemolysin III family protein -
K0P45_RS03915 (785269) 785269..786252 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
K0P45_RS03920 (786498) 786498..786764 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K0P45_RS03925 (786745) 786745..787155 + 411 WP_002916310.1 protein YgfX Toxin
K0P45_RS03930 (787162) 787162..787683 - 522 WP_004144730.1 flavodoxin FldB -
K0P45_RS03935 (787784) 787784..788680 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K0P45_RS03940 (788703) 788703..789416 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K0P45_RS03945 (789422) 789422..791155 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T211746 WP_002916310.1 NZ_CP080353:786745-787155 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T211746 NZ_CP106756:2393236-2393412 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT211746 WP_002916312.1 NZ_CP080353:786498-786764 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT211746 NZ_CP106756:2393458-2393874 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References