Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 213879..214789 Replicon plasmid pHI1B-191659
Accession NZ_CP080352
Organism Klebsiella pneumoniae strain K191659

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag K0P51_RS28070 Protein ID WP_004026354.1
Coordinates 214319..214789 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag K0P51_RS28065 Protein ID WP_004181895.1
Coordinates 213879..214322 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P51_RS28050 (K0P51_28050) 210512..211999 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
K0P51_RS28055 (K0P51_28055) 212085..212507 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
K0P51_RS28060 (K0P51_28060) 212507..213778 + 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
K0P51_RS28065 (K0P51_28065) 213879..214322 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
K0P51_RS28070 (K0P51_28070) 214319..214789 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
K0P51_RS28075 (K0P51_28075) 214899..215159 - 261 WP_004026352.1 hypothetical protein -
K0P51_RS28080 (K0P51_28080) 215731..216912 - 1182 WP_004883380.1 IS481 family transposase -
K0P51_RS28085 (K0P51_28085) 216984..217142 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
K0P51_RS28090 (K0P51_28090) 217745..218719 + 975 WP_014386572.1 hypothetical protein -
K0P51_RS28095 (K0P51_28095) 218917..219294 - 378 WP_004181901.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid armA / sul1 / qacE / aadA5 / dfrA1 / tet(B) - 1..288525 288525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T211743 WP_004026354.1 NZ_CP080352:214319-214789 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T211743 NZ_CP106756:c2209386-2209279 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT211743 WP_004181895.1 NZ_CP080352:213879-214322 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT211743 NZ_CP106756:2209434-2209500 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References