Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4704920..4705436 Replicon chromosome
Accession NZ_CP080346
Organism Klebsiella pneumoniae strain K191659

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag K0P51_RS22895 Protein ID WP_004178374.1
Coordinates 4704920..4705204 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K0P51_RS22900 Protein ID WP_002886901.1
Coordinates 4705194..4705436 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P51_RS22870 (4700315) 4700315..4700623 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
K0P51_RS22875 (4700708) 4700708..4700881 + 174 WP_032412860.1 hypothetical protein -
K0P51_RS22880 (4700884) 4700884..4701627 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K0P51_RS22885 (4701984) 4701984..4704122 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K0P51_RS22890 (4704452) 4704452..4704916 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K0P51_RS22895 (4704920) 4704920..4705204 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K0P51_RS22900 (4705194) 4705194..4705436 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K0P51_RS22905 (4705514) 4705514..4707424 - 1911 WP_004152270.1 PRD domain-containing protein -
K0P51_RS22910 (4707447) 4707447..4708601 - 1155 WP_002886900.1 lactonase family protein -
K0P51_RS22915 (4708668) 4708668..4709408 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T211737 WP_004178374.1 NZ_CP080346:c4705204-4704920 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T211737 NZ_CP106756:c646495-646121 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCGC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGAACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT211737 WP_002886901.1 NZ_CP080346:c4705436-4705194 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT211737 NZ_CP106756:c646916-646542 [Escherichia coli]
GTGTCAGACACACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGACTGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References