Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3989583..3990202 Replicon chromosome
Accession NZ_CP080346
Organism Klebsiella pneumoniae strain K191659

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K0P51_RS19540 Protein ID WP_002892050.1
Coordinates 3989984..3990202 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K0P51_RS19535 Protein ID WP_002892066.1
Coordinates 3989583..3989957 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P51_RS19525 (3984735) 3984735..3985928 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K0P51_RS19530 (3985951) 3985951..3989097 + 3147 WP_219899797.1 multidrug efflux RND transporter permease subunit AcrB -
K0P51_RS19535 (3989583) 3989583..3989957 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K0P51_RS19540 (3989984) 3989984..3990202 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K0P51_RS19545 (3990365) 3990365..3990931 + 567 WP_002892030.1 maltose O-acetyltransferase -
K0P51_RS19550 (3990903) 3990903..3991043 - 141 WP_004147370.1 hypothetical protein -
K0P51_RS19555 (3991064) 3991064..3991534 + 471 WP_002892026.1 YlaC family protein -
K0P51_RS19560 (3991509) 3991509..3992960 - 1452 WP_064151794.1 PLP-dependent aminotransferase family protein -
K0P51_RS19565 (3993061) 3993061..3993759 + 699 WP_002892021.1 GNAT family protein -
K0P51_RS19570 (3993756) 3993756..3993896 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K0P51_RS19575 (3993896) 3993896..3994159 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T211735 WP_002892050.1 NZ_CP080346:3989984-3990202 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T211735 NZ_CP106754:4566651-4566821 [Kosakonia sp. ML.JS2a]
ATGAAATACAGTGAGTTCAGAAAGTGGCTGTTGCTCATTAAAGCGCCAGGTGGAGGTAGCCATTTCAAGGTGAAATTGAA
TGGGAGGGCTTCCGTTTTTCCCTTTCACGGTTCAAAAGAAATTCCCGAGCCACTCAGAAAGAAGATTTTGAAAGACCTGG
GTCTGCAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT211735 WP_002892066.1 NZ_CP080346:3989583-3989957 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT211735 NZ_CP106754:4566851-4567288 [Kosakonia sp. ML.JS2a]
ATGTTTAATTATCCAGTCAGCGTTGAGCAAGACGACGTAACGGGACAGTTCGTTGTATCGTGCCGGGATCTTCCACTCAT
GAATTCTGTCGGCGATACACTTGATGATGCGCTCCTCCAGTCGGTTGACGCTATGGTGGTTGCGATAGCCATCGAAGTTG
ACGAACGTCGTCCCATCCCGCAGGCAAGCGCTGCCCTCCCGGGGGAATATGTGGTTTCCCTGCCGGTTCTGGTCGCGATG
AAAGCAGCACTGCACAATGCCATGATCGAAACAGGTACCCGCAAAGCTGAGCTGGCAAGAAAACTGGGACAGAAGGGCCC
CCAGATTGACCGTCTGCTTGATGTAGAGCACTCATCAAAAGTTGAAACGGTAGAACTGGCGCTGCATCAGCTAAACCGGC
AGATTGATTTAACGATTACCCAGCAACATCGAACCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References