Detailed information of TA system TA211734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2686003..2687591
• Replicon: chromosome
• Accession: NZ_CP080346
• Organism: Klebsiella pneumoniae strain K191659

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K0P51_RS13170
• Protein ID: WP_064151580.1
• Coordinates: 2686003..2687325 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K0P51_RS13175
• Protein ID: WP_004176198.1
• Coordinates: 2687325..2687591 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0P51_RS13155 (2681059)	2681059..2683560	+	2502	WP_064151582.1	fimbria/pilus outer membrane usher protein	-
K0P51_RS13160 (2683548)	2683548..2684552	+	1005	WP_064151581.1	fimbrial protein	-
K0P51_RS13165 (2684694)	2684694..2685986	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
K0P51_RS13170 (2686003)	2686003..2687325	-	1323	WP_064151580.1	type II toxin-antitoxin system HipA family toxin	Toxin
K0P51_RS13175 (2687325)	2687325..2687591	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K0P51_RS13180 (2687857)	2687857..2688183	-	327	WP_004176200.1	hydroxyisourate hydrolase	-
K0P51_RS13185 (2688180)	2688180..2688680	-	501	WP_064151579.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
K0P51_RS13190 (2688658)	2688658..2690037	-	1380	WP_065799905.1	nucleobase:cation symporter-2 family protein	-
K0P51_RS13195 (2690383)	2690383..2691537	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
K0P51_RS13200 (2691518)	2691518..2692441	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T211734 WP_064151580.1 NZ_CP080346:c2687325-2686003 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T211734 NZ_CP106754:c4530969-4530661 [Kosakonia sp. ML.JS2a]
ATGATGGGAAAGAGTAAACGCGCGCCACTTCCTTACCGTTCCGATTACACGAAAACATTTGTTAAAGCCTGGGCGCGTTA
CAACAAAGCGGGTCGCAGAGATATGCATGAAACGGCAGCAATTATGTCGATGGTGCTTTCTGGCAACCCGCTTCCGGCTC
AATATAGCGATCATGCCTTAACCGGAAATATGCATGGATTTCGCGAACTTCATCCTGGTGGCGACTACTTATTGGTTTAT
TGCGTGGATGAGGCCAAACATCTGGTGGTGTTTACGGATTTGGGTACCCACGCTGAGCTCTTTGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT211734 WP_004176198.1 NZ_CP080346:c2687591-2687325 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT211734 NZ_CP106754:c4531225-4530953 [Kosakonia sp. ML.JS2a]
ATGGATTCCGTTATCCGATCGCGTATCGACAGCGAACTGAAAGCGCGCGCCGGGCTGGTACTTGAGAGCTGTGGGCTCAA
CTGGAGCACGGCAATACGGCTGTTTGCTGAGCAAATCGTCAAAAGTGAGGGTATCCCGTTTGAGGTTACCCGCAAACCAA
CGGCACGCTTACGCAACGCGATGAGCGAAGCCAATGAGATCACCACACACCAGCATGGACGCTTTAATGGTGTTGAGCAG
CTAATGGACAGCTTAAATGATGGGAAAGAGTAA